CAS 1485-00-3|MDBN

Introduction：Basic information about CAS 1485-00-3|MDBN, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. MDBN BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	MDBN
CAS Number	1485-00-3	Molecular Weight	193.156
Density	1.4±0.1 g/cm3	Boiling Point	334.9±11.0 °C at 760 mmHg
Molecular Formula	C₉H₇NO₄	Melting Point	159-163 °C
MSDS	/	Flash Point	168.8±21.3 °C

Names

Name	3,4-Methylenedioxy-beta-nitrostyrene
Synonym	More Synonyms

MDBN BiologicalActivity

Description	MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcSignaling Pathways >>Protein Tyrosine Kinase/RTK >>SykResearch Areas >>Cancer
References	[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9. [2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.

Description

MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. target: src, syk. [1]IC50:29.3 (src), 2.5 uM (syk); [1]In vitro: no direct effects on protein kinase C, Ca2+ mobilization, Ca2+-dependent enzymes, PKC activation. MNS potently prevents GPIIb/IIIa activation and platelet aggregation without directly affecting other signaling pathways required for platelet activation. [1] [2] MNS is much more potent than genistein in inhibiting platelet aggregation and protein tyrosine phosphorylation. [2]

Related Catalog

Signaling Pathways >>Protein Tyrosine Kinase/RTK >>SrcSignaling Pathways >>Protein Tyrosine Kinase/RTK >>SykResearch Areas >>Cancer

References

[1]. Wang WY et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosinekinase inhibitor. Mol Pharmacol. 2006 Oct;70(4):1380-9.

[2]. Wang WY et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitorswith potent antiplatelet activity. Biochem Pharmacol. 2007 Aug 15;74(4):601-11.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	334.9±11.0 °C at 760 mmHg
Melting Point	159-163 °C
Molecular Formula	C₉H₇NO₄
Molecular Weight	193.156
Flash Point	168.8±21.3 °C
Exact Mass	193.037506
PSA	64.28000
LogP	2.27
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.640
Storage condition	Store at +4°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WL5270000

CHEMICAL NAME :: Styrene, 3,4-methylenedioxy-beta-nitro-

CAS REGISTRY NUMBER :: 1485-00-3

BEILSTEIN REFERENCE NO. :: 0192350

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H7-N-O4

MOLECULAR WEIGHT :: 193.17

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1U1NW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,375,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#00689

Safety Information

Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S36/37/39-S26-S45
RIDADR	UN 2811 6.1/PG 3
RTECS	WL5270000
HS Code	2932999099

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

1,3-Benzodioxole, 5- (2-nitroethenyl)-

3,4-Methylenedioxy-β-nitrostyrene

5-[(E)-2-Nitrovinyl]-1,3-benzodioxole

1,3-Benzodioxole, 5-[(E)-2-nitroethenyl]-

T56 BO DO CHJ G1U1NW

MFCD00014575

5-(2-Nitrovinyl)benzo[d][1,3]dioxole

MNS

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