CAS 15442-64-5|Zinc protoporphyrin
| Common Name | Zinc protoporphyrin | ||
|---|---|---|---|
| CAS Number | 15442-64-5 | Molecular Weight | 626.051 |
| Density | / | Boiling Point | 1128.5ºC at 760mmHg |
| Molecular Formula | C34H32N4O4Zn | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 636.3ºC |
Names
| Name | zinc protoporphyrin |
|---|---|
| Synonym | More Synonyms |
Zinc protoporphyrin BiologicalActivity
| Description | Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2[1]. Zinc Protoporphyrin is a normal metabolite formed in trace amounts during heme biosynthesis and used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration[2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseResearch Areas >>Metabolic Disease |
| References | [1]. Park C, et al. Protective Effect of Phloroglucinol on Oxidative Stress-Induced DNA Damage and Apoptosisthrough Activation of the Nrf2/HO-1 Signaling Pathway in HaCaT Human Keratinocytes. Mar Drugs. 2019 Apr 13;17(4). [2]. Mwangi MN, et al. Diagnostic utility of zinc protoporphyrin to detect iron deficiency in Kenyan pregnant women. BMC Med. 2014 Nov 26;12:229. |
Chemical & Physical Properties
| Boiling Point | 1128.5ºC at 760mmHg |
|---|---|
| Molecular Formula | C34H32N4O4Zn |
| Molecular Weight | 626.051 |
| Flash Point | 636.3ºC |
| Exact Mass | 624.171509 |
| PSA | 109.18000 |
| LogP | 3.60970 |
| Vapour Pressure | 0mmHg at 25°C |
| InChIKey | AAHFFMFJYIWDLV-UHFFFAOYSA-L |
| SMILES | C=Cc1c(C)c2cc3[nH]c(cc4nc(cc5nc(cc1[nH]2)C(C)=C5CCC(=O)[O-])C(CCC(=O)[O-])=C4C)c(C)c3C=C.[Zn+2] |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| RIDADR | NONH for all modes of transport |
Articles5
More Articles| Anti-inflammatory effect of Natterins, the major toxins from the Thalassophryne nattereri fish venom is dependent on TLR4/MyD88/PI3K signaling pathway. Toxicon 87 , 54-67, (2014) Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in ven... | |
| Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation. J. Pharmacol. Exp. Ther. 350(1) , 5-13, (2014) This study aims to investigate the effects of ramipril (RPL) on endothelial dysfunction associated with diabetes mellitus using cultured human aortic endothelial cells (HAECs) and a type 2 diabetic an... | |
| α-Tocopheryl succinate pre-treatment attenuates quinone toxicity in prostate cancer PC3 cells. Gene 539(1) , 1-7, (2014) α-Tocopheryl succinate is one of the most effective analogues of vitamin E for inhibiting cell proliferation and inducing cell death in a variety of cancerous cell lines while sparing normal cells or ... |
Synonyms
| Protoporphyrin IX zinc(II) |
| EINECS 239-455-7 |
| 21H,23H-Porphine-2,18-dipropanoic acid, 8,13-diethenyl-3,7,12,17-tetramethyl-, zinc salt (1:1) |
| MFCD00011612 |
| [3,3'-(3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphyrindiyl-κN,N)dipropanoato(2-)]zinc |
| zinc 2,18-bis(2-carboxyethyl)-7,12-diethenyl-3,8,13,17-tetramethylporphine-21,23-diide |
| Zinc 2,18-bis(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinylporphine-21,23-diide |
| PROTOPORPHYRINATO ZINC |
| zinc,3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid |
| Zinc Protoporphyrin |
| Zinc, [7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(2-)-κN,κN]- |
