CAS 128315-56-0|MCH(human, mouse, rat)
| Common Name | MCH(human, mouse, rat) | ||
|---|---|---|---|
| CAS Number | 128315-56-0 | Molecular Weight | 2386.84000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C105H160N30O26S4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | Melanin Concentrating Hormone rat |
|---|---|
| Synonym | More Synonyms |
MCH(human, mouse, rat) BiologicalActivity
| Description | MCH (human, mouse, rat) is a potent peptide agonist of MCH-R and exhibits binding IC50 values of 0.3nM and 1.5 nM for MCH1R and MCH2R, respectively. MCH (human, mouse, rat) is a highly sensitive to MCH-2R in a CHO cell line and monitoring mobilization of intracellular calcium with FLIPR, exhibits functional activation EC50 values of 3.9 nM and 0.1nM for human MCH-1R and MCH-2R, respectively[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>MCHR1 (GPR24)Research Areas >>Neurological Disease |
| Target | Binding IC50: 0.3 nM (MCH1R) IC50: 1.5 nM (MCH1R)[1] |
| References | [1]. A W Sailer, et al. Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. |
Chemical & Physical Properties
| Molecular Formula | C105H160N30O26S4 |
|---|---|
| Molecular Weight | 2386.84000 |
| Exact Mass | 2385.10000 |
| PSA | 1018.94000 |
| LogP | 6.54720 |
| InChIKey | MWLPXSMFEPHETN-QRXCLJFASA-N |
| SMILES | CSCCC1NC(=O)C(NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)NC(=O)C(Cc2ccccc2)NC(=O)C(N)CC(=O)O)CSSCC(C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCC(N)=O)C(=O)NC(C(=O)O)C(C)C)NC(=O)C2CCCN2C(=O)C(CCCNC(=N)N)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(C(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CC(C)C)NC1=O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | T+ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles3
More Articles| The receptor for the orexigenic peptide melanin-concentrating hormone is a G-protein-coupled receptor. Nat. Cell Biol. 12 , 267-271, (1999) Gene-knockout studies of melanin-concentrating hormone (MCH) and its effect on feeding and energy balance have firmly established MCH as an orexigenic (appetite-stimulating) peptide hormone. Here we i... | |
| Molecular characterization of the melanin-concentrating-hormone receptor. Nature 400 , 265-269, (1999) Orphan G-protein-coupled receptors (GPCRs) are cloned proteins with structural characteristics common to the GPCRs but that bind unidentified ligands. Orphan GPCRs have been used as targets to identif... | |
| Investigation of the feeding effects of melanin concentrating hormone on food intake--action independent of galanin and the melanocortin receptors. Brain Res. 846 , 164-170, (1999) Melanin concentrating hormone (MCH) is recognised as a hypothalamic appetite stimulant. The mechanism of action of MCH is undetermined largely due to lack of identification of hypothalamic MCH recepto... |
Synonyms
| MFCD00080193 |
| Melanin Concentrating Hormone,human,mouse |
| Melanin concentrating hormone,human,mouse,rat |
