Introduction：Basic information about CAS 148439-49-0|Prion Protein 106-126 (human), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Prion Protein 106-126 (human) |
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| CAS Number | 148439-49-0 | Molecular Weight | 1912.24000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C80H138N26O24S2 | Melting Point | / |
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| MSDS | USA | Flash Point | / |
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Names
| Name | PrP [106-126] |
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| Synonym | More Synonyms |
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Prion Protein 106-126 (human) BiologicalActivity
| Description | Prion Protein 106-126 (human) is a peptide fragment of prion, it can induct neuronal apoptosis, antiproteinase K digestion, fiber formation, and mediate the conversion of normal cellular prion protein (PrPc) into pathogenic isoform (PrPSc). Prion Protein 106-126 (human) is generally used as the model to investigate neural degeneration of prion disease[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Neurological Disease |
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| References | [1]. Forloni G, et, al. Neurotoxicity of a prion protein fragment. Nature. 1993 Apr 8; 362(6420): 543-6. [2]. Hong JM, et, al. Human prion protein-mediated calcineurin activation induces neuron cell death via AMPK and autophagy pathway. Int J Biochem Cell Biol. 2020 Feb; 119: 105680. |
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Chemical & Physical Properties
| Molecular Formula | C80H138N26O24S2 |
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| Molecular Weight | 1912.24000 |
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| Exact Mass | 1910.98000 |
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| PSA | 839.96000 |
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| LogP | 0.33420 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| Prion Protein Fragment 106-126 Human |
| N-MPPP Hydrochloride |
