CAS 154164-30-4|YM 90K hydrochloride

Introduction：Basic information about CAS 154164-30-4|YM 90K hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. YM 90K hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	YM 90K hydrochloride
CAS Number	154164-30-4	Molecular Weight	309.665
Density	/	Boiling Point	556.6ºC at 760mmHg
Molecular Formula	C₁₁H₈ClN₅O₄	Melting Point	/
MSDS	/	Flash Point	290.4ºC

Names

Name	6-imidazol-1-yl-7-nitro-1,4-dihydroquinoxaline-2,3-dione,hydrochloride
Synonym	More Synonyms

YM 90K hydrochloride BiologicalActivity

Description	YM90K is a potent and selective AMPA receptor antagonist with a Ki of 84 nM. YM90K is less potent in inhibiting kainate (Ki of 2.2 μM) and NMDA (Ki of 37 μM) receptors. YM90K has neuroprotective actions[1].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR
Target	Ki: 84 nM (AMPA receptor), 2.2 μM (Kainate receptor) and 37 μM (NMDA receptor)[1]
In Vitro	YM90K (30 nmol) co-injected with AMPA or kainate into the rat striatum protected cholinergic neurons against AMPA- or kainate-induced neurotoxicity[1].
In Vivo	YM90K showes potent suppressive activity against audiogenic seizure in DBA/2 mice; ED50 values of YM90K against tonic seizure is 2.54 mg/kg (i.p.). The duration of the anticonvulsant effects of YM90K is 30 min[1]. In a global ischemia model, YM90K (15 mg/kg i.p. x 3) significantly prevents the delayed neuronal death in the hippocampal CA1 region in Mongolian gerbils when administered 1 h after 5-min ischemia. The therapeutic time window for the neuroprotective effect of YM90K (30 mg/kg i.p. x 3) is 6 h[1]. In a focal ischemia model, YM90K (30 mg/kg i.v. bolus+10 mg/kg/h for 4 h) reduces the volume of ischemic damage in the cerebral cortex in F344 rats[1].
References	[1]. M Shimizu-Sasamata, et al. YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist. J Pharmacol Exp Ther. 1996 Jan;276(1):84-92.

Chemical & Physical Properties

Boiling Point	556.6ºC at 760mmHg
Molecular Formula	C₁₁H₈ClN₅O₄
Molecular Weight	309.665
Flash Point	290.4ºC
Exact Mass	309.026489
PSA	129.36000
LogP	1.63550
Index of Refraction	1.84
InChIKey	UMLFDVOHVJPDIZ-UHFFFAOYSA-N
SMILES	Cl.O=c1[nH]c2cc(-n3ccnc3)c([N+](=O)[O-])cc2[nH]c1=O

Synonyms

N-Acetyltryptamine

C11H7N5O4

YM 90K

ym 900

2,3-Quinoxalinedione, 1,4-dihydro-6-(1H-imidazol-1-yl)-7-nitro-, hydrochloride (1:1)

6-(1H-Imidazol-1-yl)-7-nitro-1,4-dihydro-2,3-quinoxalinedione hydrochloride (1:1)

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