CAS 19356-17-3|Calcifediol
Introduction：Basic information about CAS 19356-17-3|Calcifediol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Calcifediol | ||
|---|---|---|---|
| CAS Number | 19356-17-3 | Molecular Weight | 400.637 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 529.2±33.0 °C at 760 mmHg |
| Molecular Formula | C27H44O2 | Melting Point | 74-76oC |
| MSDS | ChineseUSA | Flash Point | 221.4±20.0 °C |
| Symbol | GHS06, GHS08 | Signal Word | Danger |
Names
| Name | calcidiol |
|---|---|
| Synonym | More Synonyms |
Calcifediol BiologicalActivity
| Description | Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). |
|---|---|
| Related Catalog | Signaling Pathways >>Vitamin D Related >>VD/VDRResearch Areas >>Metabolic DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1]. |
| References | [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 529.2±33.0 °C at 760 mmHg |
| Melting Point | 74-76oC |
| Molecular Formula | C27H44O2 |
| Molecular Weight | 400.637 |
| Flash Point | 221.4±20.0 °C |
| Exact Mass | 400.334137 |
| PSA | 40.46000 |
| LogP | 7.53 |
| Vapour Pressure | 0.0±3.2 mmHg at 25°C |
| Index of Refraction | 1.536 |
| InChIKey | JWUBBDSIWDLEOM-UHFFFAOYSA-N |
| SMILES | C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)CCCC(C)(C)O |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H311-H330-H372 |
| Precautionary Statements | P260-P280-P284-P301 + P310-P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | R28 |
| Safety Phrases | 28-36/37-45 |
| RIDADR | UN 2811 6 |
| WGK Germany | 3 |
| Packaging Group | Ⅱ |
Articles74
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| Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry. J. Chromatogr. A. 1364 , 214-22, (2014) We have developed an ultra-high-performance liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the simultaneous quantitative analyses of... | |
| Improved analysis of vitamin D metabolites in plasma using liquid chromatography tandem mass spectrometry, and its application to cardiovascular research. Biomed. Chromatogr. 28(6) , 913-7, (2014) The accurate and specific measurement of vitamin D is increasingly important for determining the role of vitamin D in the pathogenesis of disease. Liquid chromatography coupled to tandem mass spectrom... |
Synonyms
| Didrogyl |
| 1H-indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-a,a,e,7a-tetramethyl-, (eR,1R,3aS,4E,7aR)- |
| (3S,5Z,7E,20R)-9,10-Secocholesta-5,7,10-triene-3,25-diol |
| 25-hydroxyvitamin D3 |
| Ro 8-8892 |
| 25-HCC |
| U 32070E |
| Vitamin D3 25 Calcifediol |
| (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol |
| 1H-Indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-α,α,ε,7a-tetramethyl-, (εR,1R,3aS,4E,7aR)- |
| 25-hydroxycholecalciferol |
| 9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-3β,25-DIOL |
| MFCD00867077 |
| CALCIDIOL |
| Dedrogyl |
| 9,10-secocholesta-5,7,10-triene-3,25-diol, (3S,5Z,7E)- |
| 25-hydroxyvitamin D |
| 25-hydroxy-cholecalciferol |
| 9,10-Secocholesta-5,7,10(19)-triene-3b,25-diol |
| 9,10-Secocholesta-5,7,10(19)-triene-3,25-diol, (3β,5Z,7E)- |
| Calderol |
| Calcifediol |
| U-32070E |
| 1H-indene-1-pentanol, octahydro-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]-α,α,ε,7a-tetramethyl-, (1R,3aS,4E,7aR)- |
| Calcifediol,(εR,1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-α,α,ε,7a-tetramethyl-1H-indene-1-pentanol |
| EINECS 242-990-9 |
| Calcidiol,Didrogyl,Hidroferol |
| Hidroferol |
