CAS 202466-68-0|Ro 04-6790
| Common Name | Ro 04-6790 | ||
|---|---|---|---|
| CAS Number | 202466-68-0 | Molecular Weight | 308.359 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 595.8±60.0 °C at 760 mmHg |
| Molecular Formula | C12H16N6O2S | Melting Point | / |
| MSDS | USA | Flash Point | 314.1±32.9 °C |
Names
| Name | Ro 04-6790 dihydrochloride |
|---|---|
| Synonym | More Synonyms |
Ro 04-6790 BiologicalActivity
| Description | Ro 04-6790 is a potent, competitive and selective 5-HT6 receptor antagonist with pKi values of 7.26, 7.35 for rat and human 5-HT6 receptors, respectively. Ro 04-6790 has no affinity at other receptors[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT Receptor |
| Target | Rat 5-HT6 Receptor:7.26 (pKi) Human 5-HT6 Receptor:7.35 (pKi) |
| In Vitro | Ro 04-6790 has over 100 fold selective for the 5-HT6 receptor compared to other receptor binding sites (IC50>10 μM)[1]. |
| In Vivo | Ro 04-6790 (10 mg/kg, SC) produces a modest (50%) increase in ACh outflow in adult male Wistar rats of 250-300 g (this effect is not statistically different from the action of vehicle)[2]. |
| References | [1]. A J Sleight, et al. Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br J Pharmacol. 1998 Jun;124(3):556-62. [2]. Sudabeh Shirazi-Southall, et al. Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology. 2002 May;26(5):583-94. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 595.8±60.0 °C at 760 mmHg |
| Molecular Formula | C12H16N6O2S |
| Molecular Weight | 308.359 |
| Flash Point | 314.1±32.9 °C |
| Exact Mass | 308.105530 |
| PSA | 130.41000 |
| LogP | -0.52 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.700 |
| InChIKey | JELFWSXQTXRMAJ-UHFFFAOYSA-N |
| SMILES | CNc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(NC)n1 |
Safety Information
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | DA9462500 |
| HS Code | 2935009090 |
Customs
| HS Code | 2935009090 |
|---|---|
| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
Articles2
More Articles| Characterization of Ro 04-6790 and Ro 63-0563: potent and selective antagonists at human and rat 5-HT6 receptors. Br. J. Pharmacol. 124 , 556-562, (1998) 1. This study describes the in vitro characterization of two potent and selective 5-HT6 receptor antagonists at the rat and human recombinant 5-HT6 receptor. 2. In binding assays with [3H]-LSD, 4-amin... | |
| Investigation of stretching behaviour induced by the selective 5-HT6 receptor antagonist, Ro 04-6790, in rats. Br. J. Pharmacol. 126 , 1537-1542, (1999) 1. The present study examined the effects of the selective 5-HT6 receptor antagonist 4-amino-N-(2, 6 bis-methylamino-pyrimidin-4-yl)-benzene sulphonamide (Ro 04-6790) on locomotor activity and uncondi... |
Synonyms
| 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide |
| 4-Amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]benzenesulfonamide dihydrobromide |
| Benzenesulfonamide, 4-amino-N-[2,6-bis(methylamino)-4-pyrimidinyl]- |
| 4-Amino-N-[2,6-bis(methylamino)pyrimidin-4-yl]benzenesulfonamide |
| Ro 04-6790 |
| 4-amino-N-(2,6-bis-methylaminopyrimidin-4-yl)benzenesulfonamide |
