CAS 35404-50-3|(2-Iminoimidazolidin-1-yl)acetic acid
| Common Name | (2-Iminoimidazolidin-1-yl)acetic acid | ||
|---|---|---|---|
| CAS Number | 35404-50-3 | Molecular Weight | 143.144 |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 278.4±42.0 °C at 760 mmHg |
| Molecular Formula | C5H9N3O2 | Melting Point | 25-28 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 122.2±27.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Cyclocreatine |
|---|---|
| Synonym | More Synonyms |
(2-Iminoimidazolidin-1-yl)acetic acid BiologicalActivity
| Description | Cyclocreatine is a Creatine analogue and acts as a potent bioenergetic protective agent by providing high levels of ATP. Cyclocreatine crosses membranes, enters the brain, and can be phosphorylated and dephosphorylated by creatine kinases[1]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| References | [1]. Salwa A Elgebaly, et al. Cyclocreatine protects against ischemic injury and enhances cardiac recovery during early reperfusion. Expert Rev Cardiovasc Ther. 2019 Sep;17(9):683-697. [2]. Tyler K Ulland, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. 2017 Aug 10;170(4):649-663.e13. |
Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 278.4±42.0 °C at 760 mmHg |
| Melting Point | 25-28 °C(lit.) |
| Molecular Formula | C5H9N3O2 |
| Molecular Weight | 143.144 |
| Flash Point | 122.2±27.9 °C |
| Exact Mass | 143.069473 |
| PSA | 76.42000 |
| LogP | -1.99 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.660 |
| InChIKey | AMHZIUVRYRVYBA-UHFFFAOYSA-N |
| SMILES | NC1=NCCN1CC(=O)O |
| Storage condition | -20°C Freezer |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles29
More Articles| Synergistic action of dendritic mitochondria and creatine kinase maintains ATP homeostasis and actin dynamics in growing neuronal dendrites. J. Neurosci. 35(14) , 5707-23, (2015) The distribution of mitochondria within mature, differentiated neurons is clearly adapted to their regional physiological needs and can be perturbed under various pathological conditions, but the func... | |
| Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1). Neurochem. Res. 39(10) , 1988-96, (2014) The γ-aminobutyric acid (GABA) transporters (GATs) are key membrane transporter proteins involved in the termination of GABAergic signaling at synapses in the mammalian brain and proposed drug targets... | |
| Cyclocreatine inhibits stimulated motility in tumor cells possessing creatine kinase. Int. J. Cancer 78(1) , 46-52, (1998) Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine), an analog of creatine and a substrate for creatine kinase (EC 2.7.3.2), inhibits the stimulated motility of tumor cells which possess creatine kin... |
Synonyms
| 2-(2-amino-4,5-dihydroimidazol-1-yl)acetic acid |
| MFCD00134455 |
| (2-Iminoimidazolidin-1-yl)acetic acid |
| (2-Amino-4,5-dihydro-1H-imidazol-1-yl)acetic acid |
| 1H-Imidazole-1-acetic acid, 2-amino-4,5-dihydro- |
