CAS 68-94-0|Hypoxanthine
Introduction：Basic information about CAS 68-94-0|Hypoxanthine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Hypoxanthine | ||
|---|---|---|---|
| CAS Number | 68-94-0 | Molecular Weight | 136.111 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 551.0±30.0 °C at 760 mmHg |
| Molecular Formula | C5H4N4O | Melting Point | >300 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 287.0±24.6 °C |
Names
| Name | Hypoxanthine |
|---|---|
| Synonym | More Synonyms |
Hypoxanthine BiologicalActivity
| Description | Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia. |
|---|---|
| Related Catalog | Research Areas >>OthersNatural Products >>Saccharides and Glycosides |
| Target | Human Endogenous Metabolite |
| In Vitro | Hypoxanthine is a potential free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury through oxygen radical production and is therefore involved in the pathogenesis of a number of diseases. Hypoxanthine also modulates a number of other processes because it reacts with benzodiazepine receptors and inhibits phosphodiesterase in the brain. Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs[1]. |
| In Vivo | In pigs, a linear increase of plasma hypoxanthine with duration of hypoxemia is found, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. There is also a direct relationship between survival time and increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62).All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine therefore reflected the prognosis of acute hypoxia in contrast to base deficit[1]. |
| References | [1]. Saugstad OD, et al. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 551.0±30.0 °C at 760 mmHg |
| Melting Point | >300 °C(lit.) |
| Molecular Formula | C5H4N4O |
| Molecular Weight | 136.111 |
| Flash Point | 287.0±24.6 °C |
| Exact Mass | 136.038513 |
| PSA | 74.43000 |
| LogP | -0.91 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.816 |
| Storage condition | 2-8°C |
| Water Solubility | practically insoluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 750 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,201,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 1 gm/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 22,201,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6051 No. of Facilities: 64 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 541 (estimated) No. of Female Employees: 355 (estimated)
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S22-S24/25-S37/39-S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | UP0791000 |
| HS Code | 2933990090 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles248
More Articles| Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: effect of oxidative stress. Microvasc. Res. 98 , 16-22, (2015) Adenosine is an endogenous regulator of vascular tone. This activity of adenosine is terminated by its uptake and metabolism by microvascular endothelial cells (MVEC). The predominant transporter invo... | |
| In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS ONE 10 , e0134768, (2015) Dapsone (DDS) hydroxylamine metabolites cause oxidative stress- linked adverse effects in patients, such as methemoglobin formation and DNA damage. This study evaluated the ameliorating effect of the ... | |
| Oxidative stress modulates nucleobase transport in microvascular endothelial cells Microvasc. Res. 95 , 68-75, (2014) Purine nucleosides and nucleobases play key roles in the physiological response to vascular ischemia/reperfusion events. The intra- and extracellular concentrations of these compounds are controlled, ... |
Synonyms
| 3,9-Dihydro-6H-purin-6-on |
| 1,7-Dihydro-6H-purin-6-on |
| 6-Oxopurine |
| 1,7-Dihydro-6H-purin-6-one |
| 7H-Purin-6-ol |
| PURIN-6-OL |
| Hypexanthine |
| SARKIN |
| SARCINE |
| Hypoxathine |
| 3,9-Dihydro-6H-purin-6-one |
| MFCD00005725 |
| Hypoxanthine |
| Purine-6-ol |
| 6-oxypurine |
| Sarkine |
| Hypoxanthin |
| 6-Hydroxypurine |
| EINECS 200-697-3 |
| 1H,7H-Hypoxanthine |
| 1,7-dihydro-purin-6-one |
| 1,7-Dihydro-6H-purine-6-one |
