CAS 141136-83-6|TRAP-6

Introduction：Basic information about CAS 141136-83-6|TRAP-6, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. TRAP-6 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles8
6. Synonyms

Common Name	TRAP-6
CAS Number	141136-83-6	Molecular Weight	748.87000
Density	/	Boiling Point	/
Molecular Formula	C₃₄H₅₆N₁₀O₉	Melting Point	/
MSDS	ChineseUSA	Flash Point	/

Names

Name	Thrombin Receptor Activator Peptide 6
Synonym	More Synonyms

TRAP-6 BiologicalActivity

Description	TRAP-6 is a protease-activated receptor 1 (PAR1) agonist. Sequence: Ser-Phe-Leu-Leu-Arg-Asn.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Protease-Activated Receptor (PAR)PeptidesResearch Areas >>Inflammation/Immunology
References	[1]. Tripathi T, et al. Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2014 May 29;55(6):3912-21.

Chemical & Physical Properties

Molecular Formula	C₃₄H₅₆N₁₀O₉
Molecular Weight	748.87000
Exact Mass	748.42300
PSA	334.04000
LogP	1.83420
InChIKey	HAGOWCONESKMDW-FRSCJGFNSA-N
SMILES	CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)C(N)CO)C(=O)NC(CC(C)C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC(N)=O)C(=O)O
Storage condition	-20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Articles8

Clinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.

Hypertension 66 , 800-8, (2015)

Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the prote...

Impact of variables of the P-selectin - P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease.

Thromb. Haemost. 113(4) , 806-12, (2015)

The formation of leukocyte-platelet aggregates (LPA), through the P-selectin - P-selectin glycoprotein ligand (PSGL)-1 axis, plays a pivotal role in atherothrombosis. In order to investigate the influ...

Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.

J. Thromb. Haemost. 12(12) , 2074-88, (2014)

Increasing evidence implicates both platelets and neutrophils in the formation, stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps (NETs) play a key role. The...

Synonyms

MFCD00238172

(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoic acid

TRAP-6

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