CAS 9012-25-3|catechol o-methyltransferase
| Common Name | catechol o-methyltransferase | ||
|---|---|---|---|
| CAS Number | 9012-25-3 | Molecular Weight | 636.942 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 771.4±40.0 °C at 760 mmHg |
| Molecular Formula | C38H68O7 | Melting Point | / |
| MSDS | USA | Flash Point | 227.5±20.8 °C |
Names
| Name | Catechol O-methyltransferases |
|---|---|
| Synonym | More Synonyms |
catechol o-methyltransferase BiologicalActivity
| Description | Catechol O-methyltransferase (COMT) the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1]. |
|---|---|
| Related Catalog | Research Areas >>Neurological Disease |
| References | [1]. Du X, et, al. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14609-14. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 771.4±40.0 °C at 760 mmHg |
| Molecular Formula | C38H68O7 |
| Molecular Weight | 636.942 |
| Flash Point | 227.5±20.8 °C |
| Exact Mass | 636.496521 |
| LogP | 7.50 |
| Appearance of Characters | lyophilized powder |
| Vapour Pressure | 0.0±6.0 mmHg at 25°C |
| Index of Refraction | 1.507 |
| InChIKey | DGDSKYGEKMVUCF-UHFFFAOYSA-N |
| SMILES | CC(=O)OC1CC(C(C)C)=CC=C(C)CCC=C(C)CCC2OC12C |
| Storage condition | −20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles75
More Articles| Initial characterization of the human central proteome. BMC Syst. Biol. 5 , 17, (2011) On the basis of large proteomics datasets measured from seven human cell lines we consider their intersection as an approximation of the human central proteome, which is the set of proteins ubiquitous... | |
| Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 36 , 40-5, (2004) As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clone... | |
| The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 14 , 2121-7, (2004) The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for... |
Synonyms
| MFCD00081488 |
| 2(5H)-Furanone, 3-[13-[5'-(1,5-dihydroxyundecyl)octahydro[2,2'-bifuran]-5-yl]-13-hydroxy-3-methyltridecyl]-5-methyl- |
| EINECS 232-727-6 |
| 3-{13-[5'-(1,5-Dihydroxyundecyl)octahydro-2,2'-bifuran-5-yl]-13-hydroxy-3-methyltridecyl}-5-methyl-2(5H)-furanone |
