Introduction：Basic information about CAS 59143-60-1|Cephalosporin C zinc salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cephalosporin C zinc salt |
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| CAS Number | 59143-60-1 | Molecular Weight | 478.78 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 814.7±65.0 °C at 760 mmHg |
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| Molecular Formula | C16H19N3O8SZn | Melting Point | 240-242°C |
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| MSDS | / | Flash Point | 446.5±34.3 °C |
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Names
| Name | Cephalosporin C Zinc Salt |
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| Synonym | More Synonyms |
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Cephalosporin C zinc salt BiologicalActivity
| Description | Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| Target | IC50: 1.1 μM (SAMHD1)[1] |
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| In Vitro | Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM)[1]. |
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| References | [1]. Seamon KJ, et al. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 814.7±65.0 °C at 760 mmHg |
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| Melting Point | 240-242°C |
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| Molecular Formula | C16H19N3O8SZn |
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| Molecular Weight | 478.78 |
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| Flash Point | 446.5±34.3 °C |
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| LogP | -0.20 |
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| Vapour Pressure | 0.0±6.3 mmHg at 25°C |
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| Index of Refraction | 1.639 |
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| InChIKey | MGNGNKZZUPFEAN-OOARYINLSA-N |
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| SMILES | CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)CCCC(N)C(=O)O)C2SC1.[Zn] |
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| Storage condition | 2-8°C |
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Safety Information
| Hazard Codes | Xn |
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| Risk Phrases | 42/43 |
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| Safety Phrases | 22-45 |
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| WGK Germany | 3 |
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Synonyms
| 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-7-[[(5R)-5-amino-5-carboxy-1-oxopentyl]amino]-8-oxo-, (6R,7R)- |
| (6R,7R)-3-(Acetoxymethyl)-7-{[(5R)-5-amino-5-carboxypentanoyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid |
| cephalosporin |
| Cephalosporin C |
