Introduction：Basic information about CAS 803647-40-7|NSC59984, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NSC59984 |
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| CAS Number | 803647-40-7 | Molecular Weight | 265.265 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 451.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C12H15N3O4 | Melting Point | / |
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| MSDS | / | Flash Point | 227.1±28.7 °C |
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Names
| Name | 1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one |
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| Synonym | More Synonyms |
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NSC59984 BiologicalActivity
| Description | NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells.IC50 value: 8.38 μM (EC50, for p53-null HCT116 cells)Target: p53in vitro: NSC59984 specifically restores p53 pathway signaling in mutant p53-expressing human colorectal cancer cells. NSC59984 induces cell death in tumor cells but not normal cells with little or no genotoxicity. NSC59984 induces mutant p53 protein degradation through MDM2-mediated ubiquitination in cancer cells. NSC59984 restores p53 pathway signaling through activation of p73. NSC59984 induces p73-dependent cell apoptosis in cancer.in vivo: NSC59984 synergizes with CPT11 to induce cell death in mutant p53-expressing colorectal cancer cells and inhibits mutant p53-associated colon tumor xenograft growth in a p73-dependent manner. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>MDM-2/p53Research Areas >>Cancer |
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| References | [1]. Zhang S, et al. Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 451.8±45.0 °C at 760 mmHg |
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| Molecular Formula | C12H15N3O4 |
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| Molecular Weight | 265.265 |
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| Flash Point | 227.1±28.7 °C |
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| Exact Mass | 265.106262 |
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| LogP | 0.82 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.596 |
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| InChIKey | QKTRIGNWBRHBFV-DUXPYHPUSA-N |
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| SMILES | CN1CCN(C(=O)C=Cc2ccc([N+](=O)[O-])o2)CC1 |
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| Storage condition | -20℃ |
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Synonyms
| (2E)-1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furyl)-2-propen-1-one |
| 2-Propen-1-one, 1-(4-methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-, (2E)- |
| NSC59984 |
