CAS 1405-89-6|Bacitracin zinc

Introduction：Basic information about CAS 1405-89-6|Bacitracin zinc, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Bacitracin zinc BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles31
6. Synonyms

Common Name	Bacitracin zinc
CAS Number	1405-89-6	Molecular Weight	1488.101
Density	/	Boiling Point	/
Molecular Formula	C₆₆H₁₀₁N₁₇O₁₆SZn	Melting Point	250 ºC (dec.)
MSDS	ChineseUSA	Flash Point	/

Names

Name	Zinc bacitracin
Synonym	More Synonyms

Bacitracin zinc BiologicalActivity

Description	Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.Target: AntibacterialBacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis [1, 2].
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection
References	[1]. Murphy, T., et al., Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. J Biotechnol, 2007. 131(4): p. 397-403. [2]. Karala, A.R. and L.W. Ruddock, Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J, 2010. 277(11): p. 2454-62.

Description

Bacitracin Zinc is a dephosphorylation of the C55-isoprenyl pyrophosphate interference for inhibition of cleavage of Tyr from Met-enkephalin with IC50 of 10 μM.Target: AntibacterialBacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn't work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis [1, 2].

Related Catalog

Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

References

[1]. Murphy, T., et al., Effect of oligosaccharide elicitors on bacitracin A production and evidence of transcriptional level control. J Biotechnol, 2007. 131(4): p. 397-403.

[2]. Karala, A.R. and L.W. Ruddock, Bacitracin is not a specific inhibitor of protein disulfide isomerase. FEBS J, 2010. 277(11): p. 2454-62.

Chemical & Physical Properties

Melting Point	250 ºC (dec.)
Molecular Formula	C₆₆H₁₀₁N₁₇O₁₆SZn
Molecular Weight	1488.101
Exact Mass	1485.677002
Storage condition	2-8°C
Water Solubility	5.1 g/L (28 ºC)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles31

Clearance of nasal Staphylococcus aureus colonization with triple antibiotic ointment.

Journal. of. Drugs in. Dermatology. 11(12) , 1490-2, (2012)

The prevalence of Staphylococcus aureus colonization of healthcare workers is reported at 30%, with colonization rates for methicillin-resistant S aureus (MRSA) reported between 2.0% and 8.5% among in...

Role of topical antibiotic prophylaxis in prevention of bacterial translocation into upper trachea in nasally intubated patients undergoing tonsillectomies.

Int. J. Pediatr. Otorhinolaryngol. 77(2) , 270-4, (2013)

The human oropharynx and nasopharynx are home of different bacteria and fungi. The initial sterile endotracheal tube (ETT) transfers mechanically the bacteria from the nasopharynx and oropharynx to th...

Alteration of bile acid metabolism in pseudo germ-free rats [corrected].

Arch. Pharm. Res. 35(11) , 1969-77, (2012)

To characterize the impact of gut microbiota on host bile acid metabolism, we investigated the metabolic profiles of oxysterols and bile acids (BAs) in a conventional rat model (SD) (n=5) and its pseu...

Synonyms

Bacitracin zinc

EINECS 215-787-8

L-isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9-

Bacitracin zinc salt

MFCD00130598

L-isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9-(1H-imidazol-5-ylmethyl)-15-(1-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-12-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclopentacos-21-yl]-, zinc salt (1:1)

L-Isoleucinamide, N-[[2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl]carbonyl]-L-leucyl-D-α-glutamyl-N-[(3S,6R,9S,12R,15S,18R,21S)-3-(2-amino-2-oxoethyl)-18-(3-aminopropyl)-6-(carboxymethyl)-9- (1H-imidazol-5-ylmethyl)-15-(1-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-12-(phenylmethyl)-1,4,7,10,13,16,19-heptaazacyclopentacos-21-yl]-, zinc salt (1:1)

Bacitracin (Zinc)

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