CAS 957-66-4|Isolinderalactone
Introduction：Basic information about CAS 957-66-4|Isolinderalactone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isolinderalactone | ||
|---|---|---|---|
| CAS Number | 957-66-4 | Molecular Weight | 244.29 |
| Density | / | Boiling Point | / |
| Molecular Formula | C15H16O3 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | (3aS,8bR)-4,8-dimethyl-3-methylene-4-vinyl-3a,4,5,8b-tetrahydrobenzo[1,2-b:3,4-b']difuran-2(3H)-one |
|---|---|
| Synonym | More Synonyms |
Isolinderalactone BiologicalActivity
| Description | Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells[1]. Isolinderalactone suppresses the expression of B-cell lymphoma 2 (Bcl-2), survi |
|---|---|
| Related Catalog | Signaling Pathways >>Apoptosis >>Bcl-2 FamilyResearch Areas >>CancerSignaling Pathways >>Apoptosis >>SurvivinSignaling Pathways >>Apoptosis >>IAPSignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
| Target | VEGFR2 Bcl-2 |
| References | [1]. Park JH, et al. Isolinderalactone suppresses human glioblastoma growth and angiogenic activity in 3D microfluidic chip and in vivo mouse models. Cancer Lett. 2020;478:71-81. [2]. Hwang JY, et al. Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model. Cancer Lett. 2019;443:25-33. |
Chemical & Physical Properties
| Molecular Formula | C15H16O3 |
|---|---|
| Molecular Weight | 244.29 |
| Exact Mass | 244.11000 |
| PSA | 39.44000 |
| LogP | 3.10670 |
| InChIKey | VXZIFOKTSURLNL-YDHLFZDLSA-N |
| SMILES | C=CC1(C)Cc2occ(C)c2C2OC(=O)C(=C)C21 |
| Storage condition | -20℃ |
Synonyms
| Isolinderalactone |
