Introduction：Basic information about CAS 1441674-54-9|Ledipasvir (acetone), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Ledipasvir (acetone) |
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| CAS Number | 1441674-54-9 | Molecular Weight | 947.079 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C52H60F2N8O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Ledipasvir acetone |
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| Synonym | More Synonyms |
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Ledipasvir (acetone) BiologicalActivity
| Description | Ledipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>HCV ProteaseSignaling Pathways >>Anti-infection >>HCVResearch Areas >>Infection |
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| In Vitro | Ledipasvir acetone is considered the active pharmaceutical ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base. |
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Chemical & Physical Properties
| Molecular Formula | C52H60F2N8O7 |
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| Molecular Weight | 947.079 |
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| Exact Mass | 946.455322 |
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| PSA | 191.71000 |
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| LogP | 9.86020 |
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| Storage condition | 2-8℃ |
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Synonyms
| Ledipasvir (acetone) |
| Carbamic acid, N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]-, methyl ester, compd. with 2-propanone (1:1) |
| Ledipasvir compd. with acetone |
| Methyl [(2S)-1-{(1R,3S,4S)-3-[6-(9,9-difluoro-7-{2-[(6S)-5-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-5-azaspiro[2.4]hept-6-yl]-1H-imidazol-5-yl}-9H-fluoren-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl}-3-methyl-1-oxo-2-butanyl]carbamate - acetone (1:1) |
| Ledipasvir (GS5885) acetone |
