Introduction：Basic information about CAS 1137109-21-7|Mal-amido-PEG6-NHS ester, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Mal-amido-PEG6-NHS ester |
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| CAS Number | 1137109-21-7 | Molecular Weight | 601.60000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C26H39N3O13 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Mal-PEG6-NHS |
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| Synonym | More Synonyms |
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Mal-amido-PEG6-NHS ester BiologicalActivity
| Description | Mal-amido-PEG6-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | PEGs Alkyl/ether |
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| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
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| References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. |
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Chemical & Physical Properties
| Molecular Formula | C26H39N3O13 |
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| Molecular Weight | 601.60000 |
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| Exact Mass | 601.24800 |
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| PSA | 185.54000 |
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| InChIKey | AVCPTIUOZBWCKE-UHFFFAOYSA-N |
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| SMILES | O=C(CCN1C(=O)C=CC1=O)NCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O |
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| Storage condition | -20°C |
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Safety Information
| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| α-Maleimidopropionyl-ω-succinimidyl-6(ethylene glycol) |
