CAS 19595-18-7|25S-Inokosterone

Introduction：Basic information about CAS 19595-18-7|25S-Inokosterone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common Name25S-Inokosterone
CAS Number19595-18-7Molecular Weight480.63400
Density/Boiling Point/
Molecular FormulaC27H44O7Melting Point/
MSDS/Flash Point/

Names

Nameinokosterone
SynonymMore Synonyms

25S-Inokosterone BiologicalActivity

Description25S-Inokosterone is a phytoecdysone in the roots of two same species of A. bidentata Blume and A. japonica Nakai, and two different species of C. capitata Moq and C. officinalis Kuan. 25S-Inokosterone has the potential for the LPS-induced acute kidney injury research[1][2].
Related CatalogSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
In Vitro25S-Inokosterone (10 μM) significantly promotes the proliferation of LPS-induced NRK52e cells (1.0 μg/mL LPS). 25S-Inokosterone significantly reduces the rate of NRK52e cells apoptosis[1]. 25S-Inokosterone shows weak inhibitory activity for thymus and activation-regulated chemokine expression levels in TNF-α plus IFN-γ induced HaCaT cells. 25S-Inokosterone exhibits the most potent inhibition (80-95% at 200 µg/mL) against TNF-α expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells[3].
References

[1]. Shengchao Wang, et al. Raw and salt-processed Achyranthes bidentata attenuate LPS-induced acute kidney injury by inhibiting ROS and apoptosis via an estrogen-like pathway. Biomed Pharmacother

[2]. Bing Tian Zhao, et al. High performance liquid chromatography used for quality control of Achyranthis Radix. Arch Pharm Res. 2012 Aug;35(8):1449-55.

[3]. K. Kim, et al.Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity. J Appl Biol Chem (2015) 58(1), 13-19.

Chemical & Physical Properties

Molecular FormulaC27H44O7
Molecular Weight480.63400
Exact Mass480.30900
PSA138.45000
LogP1.71150
InChIKeyJQNVCUBPURTQPQ-BMZRUTLMSA-N
SMILESCC(CO)CCC(O)C(C)(O)C1CCC2(O)C3=CC(=O)C4CC(O)C(O)CC4(C)C3CCC12C

Synonyms

25S-Inokosterone
Inokosteron
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