Introduction：Basic information about CAS 1246535-95-4|Desmethyl VS-5584, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Desmethyl VS-5584 |
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| CAS Number | 1246535-95-4 | Molecular Weight | 340.383 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 669.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C16H20N8O | Melting Point | / |
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| MSDS | / | Flash Point | 358.6±34.3 °C |
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Names
| Name | 5-(9-isopropyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine |
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| Synonym | More Synonyms |
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Desmethyl VS-5584 BiologicalActivity
| Description | Desmethyl-VS-5584 is a dimethyl analog of VS-5584 which is an potent and selective mTOR/PI3K dual inhibitor with pyrido [2,3-d] pyrimidine structure[1]. |
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| Related Catalog | Signaling Pathways >>PI3K/Akt/mTOR >>mTORResearch Areas >>CancerSignaling Pathways >>PI3K/Akt/mTOR >>PI3K |
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| References | [1]. Hart S, Novotny-Diermayr V, Goh KC, et al. VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. Mol Cancer Ther. 2013;12(2):151-161. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 669.3±65.0 °C at 760 mmHg |
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| Molecular Formula | C16H20N8O |
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| Molecular Weight | 340.383 |
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| Flash Point | 358.6±34.3 °C |
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| Exact Mass | 340.175995 |
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| PSA | 107.87000 |
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| LogP | -0.67 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.766 |
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| InChIKey | NGDDJJKHNGAOCH-UHFFFAOYSA-N |
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| SMILES | CC(C)n1cnc2c(-c3cnc(N)nc3)nc(N3CCOCC3)nc21 |
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| Storage condition | -20℃ |
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Synonyms
| 2-Pyrimidinamine, 5-[9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]- |
| 5-[9-Isopropyl-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine |
| 5-(9-isopropyl-2-morpholin-4-yl-9H-purin-6-yl)-pyrimidin-2-ylamine |
| 5-(9-isopropyl-2-morpholin-4-yl-9H-purin-6-yl)pyrimidin-2-ylamine |
| Desmethyl VS-5584 |
