CAS 1535212-07-7|voxilaprevir

Introduction：Basic information about CAS 1535212-07-7|voxilaprevir, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. voxilaprevir BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	voxilaprevir
CAS Number	1535212-07-7	Molecular Weight	868.93400
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₄₀H₅₂F₄N₆O₉S	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	voxilaprevir
Synonym	More Synonyms

voxilaprevir BiologicalActivity

Description	Voxilaprevir (GS-9857) is a fluorinated macrocyclic hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease inhibitor with potent in vitro antiviral activity against genotypes 1-6 HCV and broad coverage of NS3/4A protease polymorphisms. GS-9857 improves coverage against commonly encountered NS3 resistance-associated variants (RAVs)[1][2].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>HCV Protease
Target	Hepatitis C virus (HCV) nonstructural protein (NS) 3/4A protease[1]
References	[1]. Rodriguez-Torres M, et al. GS-9857 in patients with chronic hepatitis C virus genotype 1-4 infection: a randomized, double-blind, dose-ranging phase 1 study. J Viral Hepat. 2016 Aug;23(8):614-22. [2]. Lawitz E, et al. Efficacy of Sofosbuvir, Velpatasvir, and GS-9857 in Patients With Genotype 1 Hepatitis C VirusInfection in an Open-Label, Phase 2 Trial. Gastroenterology. 2016 Nov;151(5):893-901.e1.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Molecular Formula	C₄₀H₅₂F₄N₆O₉S
Molecular Weight	868.93400
Exact Mass	868.34500
PSA	203.60000
LogP	3.83
Index of Refraction	1.596
Storage condition	2-8°C
Water Solubility	Insuluble (2.8E-4 g/L) (25 ºC)

Synonyms

voxilaprevir

GS-9857

(1R,18R,20R,24S,27S,28S)-N-[(1R,2R)-2-(Difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-28-ethyl-13,13-difluoro-7-methoxy-24-(2-methyl-2-propanyl)-22,25-dioxo-2,21-dioxa-4,11,2 ;3,26-tetraazapentacyclo[24.2.1.0.0.0]nonacosa-3(12),4,6,8,10-pentaene-27-carboxamide

8H-7,10-Methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide, N-[(1R,2R)-2-(difluoromethyl)-1-[[[(1-methylcyclopropyl)sulfonyl]amino]carbonyl]cyclopropyl]-5-(1,1-dimethylethyl)-9-ethyl-18,18-difluoro-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-14-methoxy-3,6-dioxo-, (1aR,5S,8S,9S,10R,22aR)-

UNII:0570F37359

voxilaprevirum

(1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1 R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14- methoxy-3,6-dioxo-1,1a,3,4,5,6,9,1 0,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide

(1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]-9-ethyl-18,18-difluoro-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide

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