Introduction：Basic information about CAS 914638-30-5|IDO-IN-1, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | IDO-IN-1 |
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| CAS Number | 914638-30-5 | Molecular Weight | 316.08700 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C9H7BrFN5O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide |
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| Synonym | More Synonyms |
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IDO-IN-1 BiologicalActivity
| Description | IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Indoleamine 2,3-Dioxygenase (IDO)Research Areas >>Cancer |
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| Target | IDO:59 nM (IC50) IDO:12 nM (IC50, in HeLa cell) |
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| In Vitro | IDO-IN-1 (Compound 5m) is a potent (HeLa IC50=12 nM) inhibitor of IDO[1]. |
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| References | [1]. Yue EW, et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem. 2009 Dec 10;52(23):7364-7. |
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Chemical & Physical Properties
| Molecular Formula | C9H7BrFN5O2 |
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| Molecular Weight | 316.08700 |
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| Exact Mass | 314.97700 |
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| PSA | 109.56000 |
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| LogP | 2.45550 |
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| InChIKey | ORHZJUSHZUCMKR-UHFFFAOYSA-N |
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| SMILES | Nc1nonc1C(=Nc1ccc(F)c(Br)c1)NO |
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Synonyms
| IDO-IN-1 |
| 4-amino-N(3-bromo-4-fluorophenyl)-N-hydroxy- |
