Introduction：Basic information about CAS 119400-86-1|Salviolone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Salviolone |
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| CAS Number | 119400-86-1 | Molecular Weight | 268.35000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H20O2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Salviolone |
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| Synonym | More Synonyms |
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Salviolone BiologicalActivity
| Description | Salviolone is a natural diterpenoid derivative that can against melanoma cells. Salviolone exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATResearch Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>STAT |
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| In Vitro | Salviolone (5-60 μM; 72 hours) 降低 A375 和 MeWo 黑色素瘤细胞系的细胞活力，EC50 值分别为 17 μM 和 22 μM。Salviolone 不影响正常黑素细胞的生长[1]。Salviolone (20 μM; 48-72 hours) 强烈降低 A375 细胞中的 pRb、pCdk2 和细胞周期蛋白 A2、Tyr705-STAT3 磷酸化表达水平。Salviolone 还强烈增加 P21 和 P53 蛋白表达水平。Salviolone 诱导 ERK1/2 和 Akt 磷酸化的持续激活[1]。Salviolone (10-20 μM) 抑制 A375 黑色素瘤细胞系中的 MMP2 明胶酶活性[1]。 Cell Viability Assay[1] Cell Line: A375, MeWo melanoma cells, and NHEM cells Concentration: 5 μM, 10 μM, 20 μM, 30 μM, 40 μM, 50 μM, 60 μM Incubation Time: 72 hours Result: Impaired the viability of melanoma cells without affecting the growth of normal melanocytes. Western Blot Analysis[1] Cell Line: A375 cells Concentration: 20 μM Incubation Time: 48 hours, 72 hours Result: Reduced the expression of the active forms of Cdk2 (pCdk2) and cyclin A2, and the phosphorylation of Rb. |
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| References | [1]. Valentina Zanrè, et al. Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation. Int J Mol Sci. 2022 Jan 20;23(3):1121. |
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Chemical & Physical Properties
| Molecular Formula | C18H20O2 |
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| Molecular Weight | 268.35000 |
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| Exact Mass | 268.14600 |
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| PSA | 37.30000 |
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| LogP | 3.82790 |
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| InChIKey | QATRODNHXVHGNU-UHFFFAOYSA-N |
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| SMILES | Cc1cc2ccc3c(c2cc(=O)c1O)CCCC3(C)C |
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Synonyms
| 10-Hydroxy-4,4,8-trimethyl-1,2,3,4-tetrahydro-cyclohepta[a]naphthalen-9-one |
