Introduction：Basic information about CAS 1262780-97-1|Etelcalcetide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Etelcalcetide |
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| CAS Number | 1262780-97-1 | Molecular Weight | 1048.25000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C38H73N21O10S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Etelcalcetide |
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| Synonym | More Synonyms |
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Etelcalcetide BiologicalActivity
| Description | Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis[1]. |
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| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>CaSR |
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| References | [1]. Block GA, et al. Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial. JAMA. 2017 Jan 10;317(2):156-164. |
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Chemical & Physical Properties
| Molecular Formula | C38H73N21O10S2 |
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| Molecular Weight | 1048.25000 |
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| Exact Mass | 1047.53000 |
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| PSA | 608.31000 |
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| LogP | 1.67200 |
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| InChIKey | ANIAZGVDEUQPRI-ZJQCGQFWSA-N |
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| SMILES | CC(=O)NC(CSSCC(N)C(=O)O)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(N)=O |
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| Storage condition | 2-8°C |
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Synonyms
| Velcalcetide |
| AMG 416 |
| KAI 4169 |
| ONO 5163 |
| Telcalcetide |
| Parsabiv |
| H-Cys(1)-OH.Ac-D-Cys(1)-D-Ala-D-Arg-D-Arg-D-Arg-D-Ala-D-Arg-NH2 |
| N-acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine |
| N-acetyl-D-cysteinyl-S-(L-cysteine disulfide)-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide |
