CAS 123048-17-9|Phyltetralin

Introduction：Basic information about CAS 123048-17-9|Phyltetralin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Phyltetralin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Phyltetralin
CAS Number	123048-17-9	Molecular Weight	416.51
Density	/	Boiling Point	/
Molecular Formula	C₂₄H₃₂O₆	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	(+)-phyltetralin
Synonym	More Synonyms

Phyltetralin BiologicalActivity

Description	Phyltetralin (Compound 10) is a natural product than can be isolated from the hexane-ethyl acetate extract of Phyllanthus amarus leaves. Phyltetralin possesses immunosuppressive effects on different lineages of innate immune system[1][2].
Related Catalog	Signaling Pathways >>Protein Tyrosine Kinase/RTK >>ROSResearch Areas >>Inflammation/Immunology
In Vitro	Phyltetralin shows inhibition on Polymorphonuclear neutrophil (PMN) chemotaxis with an IC50 of 4.01 µM[2]. Phyltetralin shows strong inhibition against reactive oxygen species (ROS) production from PMA-stimulated neutrophil with an IC50 of 0.73 µM[2]. Phyltetralin shows weak inhibition on CD18 expression and moderate inhibition on engulfment activity[2].
References	[1]. Conrado GG, et al. Prospecting and Identifying Phyllanthus amarus Lignans with Antileishmanial and Antitrypanosomal Activity. Planta Med. 2020 Jul;86(11):782-789. [2]. Yuandani, et al. 1, 7, 8-trihydroxy 2-naphtaldehyde, ethyl 8-hydroxy-8-methyl-tridecanoate and 1-triacontanol from Phyllanthus amarus Schumach. & Thonn. inhibit phagocytic activity of human leucocytes[J]. Journal of Pharmacy and Pharmacology, 2019, 71(9): 1451-1457.

Chemical & Physical Properties

Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.51
Exact Mass	416.22000
PSA	55.38000
LogP	3.93420
InChIKey	CZZKSEXMNQGXJU-ROMRWMGNSA-N
SMILES	COCC1Cc2cc(OC)c(OC)cc2C(c2ccc(OC)c(OC)c2)C1COC

Synonyms

phyltetralin

(1R,2S,3S)-1-(3,4-Dimethoxy-phenyl)-6,7-dimethoxy-2,3-bis-methoxymethyl-1,2,3,4-tetrahydro-naphthalene

Phyltetralin

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