Introduction：Basic information about CAS 1110766-97-6|Lusutrombopag, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lusutrombopag |
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| CAS Number | 1110766-97-6 | Molecular Weight | 591.546 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C29H32Cl2N2O5S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Lusutrombopag |
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| Synonym | More Synonyms |
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Lusutrombopag BiologicalActivity
| Description | Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease. |
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| Related Catalog | Signaling Pathways >>Immunology/Inflammation >>Thrombopoietin ReceptorResearch Areas >>Inflammation/Immunology |
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| In Vitro | Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels[1]. |
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| References | [1]. Kim ES, et al. Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Molecular Formula | C29H32Cl2N2O5S |
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| Molecular Weight | 591.546 |
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| Exact Mass | 590.140869 |
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| LogP | 8.64 |
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| Index of Refraction | 1.618 |
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| InChIKey | NOZIJMHMKORZBA-KJCUYJGMSA-N |
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| SMILES | CCCCCCOC(C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(C=C(C)C(=O)O)c(Cl)c3)n2)c1OC |
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| Storage condition | 2-8℃ |
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Synonyms
| S-888711 |
| Acide (2E)-3-{2,6-dichloro-4-[(4-{3-[(1S)-1-(hexyloxy)éthyl]-2-méthoxyphényl}-1,3-thiazol-2-yl)carbamoyl]phényl}-2-méthylacrylique |
| (2E)-3-{2,6-Dichloro-4-[(4-{3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl}-1,3-thiazol-2-yl)carbamoyl]phenyl}-2-methylacrylic acid |
| 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- |
| (2E)-3-{2,6-Dichlor-4-[(4-{3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl}-1,3-thiazol-2-yl)carbamoyl]phenyl}-2-methylacrylsäure |
