CAS 8068-28-8|Colistin methanesulfonate sodium salt
| Common Name | Colistin methanesulfonate sodium salt | ||
|---|---|---|---|
| CAS Number | 8068-28-8 | Molecular Weight | 1759.898 |
| Density | / | Boiling Point | / |
| Molecular Formula | C58H115N16Na5O28S5 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | colistin methanesulfonate sodium salt |
|---|---|
| Synonym | More Synonyms |
Colistin methanesulfonate sodium salt BiologicalActivity
| Description | Colistin methanesulfonate sodium salt exhibits MIC values ranged from 4 to 16 mg/liter against susceptible strains (P. aeruginosa)[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| In Vitro | Colistin methanesulfonate is less bactericidal than colistin at the same multiples of the MIC. Colistin and colistin methanesulfonate are both unequal mixtures of the salts of two components, colistins A and B (1), which may well have different in vitro activities[1]. |
| References | [1]. Jian Li, et al. In Vitro Pharmacodynamic Properties of Colistin and Colistin Methanesulfonate against Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis. Antimicrob Agents Chemother. 2001 Mar; 45(3): 781–785. |
Chemical & Physical Properties
| Molecular Formula | C58H115N16Na5O28S5 |
|---|---|
| Molecular Weight | 1759.898 |
| Exact Mass | 1758.615845 |
| Appearance of Characters | white to faintly beige |
| InChIKey | IQWHCHZFYPIVRV-UHFFFAOYSA-I |
| SMILES | CCC(C)CCCCC(=O)NC(CCNCS(=O)(=O)[O-])C(=O)NC(C(=O)NC(CCNCS(=O)(=O)[O-])C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCNCS(=O)(=O)[O-])NC(=O)C(CCNCS(=O)(=O)[O-])NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCNCS(=O)(=O)[O-])NC1=O)C(C)O.[Na+].[Na+].[Na+].[Na+].[Na+] |
| Storage condition | 2-8°C |
| Water Solubility | H2O: soluble10mg/mL |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | 3249 |
| WGK Germany | 2 |
| RTECS | GH1650000 |
Articles33
More Articles| High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate. J. Chromatogr. A. 1369 , 52-63, (2014) Colistin is a last resort's antibacterial treatment in critically ill patients with multi-drug resistant Gram-negative infections. As appropriate colistin exposure is the key for maximizing efficacy w... | |
| Lung Microbiota Changes Associated with Chronic Pseudomonas aeruginosa Lung Infection and the Impact of Intravenous Colistimethate Sodium. PLoS ONE 10 , e0142097, (2015) Exacerbations associated with chronic lung infection with Pseudomonas aeruginosa are a major contributor to morbidity, mortality and premature death in cystic fibrosis. Such exacerbations are treated ... | |
| In vitro pharmacodynamic properties of colistin and colistin methanesulfonate against Pseudomonas aeruginosa isolates from patients with cystic fibrosis. Antimicrob. Agents Chemother. 45 , 781-785, (2001) The in vitro pharmacodynamic properties of colistin and colistin methanesulfonate were investigated by studying the MICs, time-kill kinetics, and postantibiotic effect (PAE) against mucoid and nonmuco... |
Synonyms
| Colistrimethate sodium |
| EINECS 232-516-9 |
| MFCD00130824 |
| Colimycin M |
| Colistimethate sodium |
| Sodium colistimethate |
| Colistin sodium methanesulfonate |
| Colistimethate |
| Sodium methanesulfonate - N-[(2S)-4-amino-1-{[(2S,3R)-1-{[(2S)-4-amino-1-oxo-1-({(6S,9R,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-3-[(1R)-1-hydroxyethyl]-12,15-diisobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl}amino)-2-butanyl]amino}-3-hydroxy-1-oxo-2-butanyl]amino}-1-oxo-2-butanyl]-6-methyloctanamide (5:5:1) |
