Introduction：Basic information about CAS 918629-48-8|Transdermal Peptide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Transdermal Peptide |
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| CAS Number | 918629-48-8 | Molecular Weight | 1063.17000 |
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| Density | 1.450±0.06 g/cm3 | Boiling Point | / |
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| Molecular Formula | C40H66N14O16S2 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | td-1 |
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| Synonym | More Synonyms |
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Transdermal Peptide BiologicalActivity
| Description | Transdermal Peptide is a 11-amino acid peptide, binds to Na+/K+-ATPase beta-subunit (ATP1B1), and enhances the transdermal delivery of many macromolecules. |
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| Related Catalog | Signaling Pathways >>Others >>OthersPeptidesResearch Areas >>Others |
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| In Vitro | Transdermal Peptide (TD1) binds to ATP1B1, and mainly interacts with the C-terminus of ATP1B1 in yeast and mammalian cells. The interaction affects the expression and localization of ATP1B1 and epidermal structure, but can be antagonized by the exogenous competitor ATP1B1 or be inhibited by ouabain. Inhibition of Transdermal Peptide binding to ATP1B1 causes decreased delivery of macromolecular drugs across the skin[1]. |
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| References | [1]. Wang C, et al. Role of the Na(+)/K(+)-ATPase beta-subunit in peptide-mediated transdermal drug delivery. Mol Pharm. 2015 Apr 6;12(4):1259-67. |
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Chemical & Physical Properties
| Density | 1.450±0.06 g/cm3 |
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| Molecular Formula | C40H66N14O16S2 |
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| Molecular Weight | 1063.17000 |
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| Exact Mass | 1062.42000 |
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| PSA | 558.75000 |
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| Water Solubility | Very soluble (1000 g/L) (25 ºC) |
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Synonyms
| Transdermal Peptide |
| L-Alanyl-L-cysteinyl-L-seryl-L-seryl-L-seryl-L-prolyl-L-seryl-L-lysyl-L-histidyl-L-cysteinylglycine |
