Introduction：Basic information about CAS 21705-02-2|ε-Amanitin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ε-Amanitin |
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| CAS Number | 21705-02-2 | Molecular Weight | 903.95500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C39H53N9O14S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | ε-Amanitin |
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| Synonym | More Synonyms |
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ε-Amanitin BiologicalActivity
| Description | ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Antibody-drug Conjugate >>ADC Cytotoxin |
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| Target | Traditional Cytotoxic Agents |
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| In Vitro | Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1]. |
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| References | [1]. Jan Grunewald, et al. Amatoxin derivatives and conjugates thereof as inhibitors of rna polymerase. WO2016071856A1. [2]. Kaya E, et al. Amanitin and phallotoxin concentration in Amanita phalloides var. alba mushroom. Toxicon. 2013;76:225-233. |
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Chemical & Physical Properties
| Molecular Formula | C39H53N9O14S |
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| Molecular Weight | 903.95500 |
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| Exact Mass | 903.34300 |
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| PSA | 374.07000 |
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| InChIKey | OFILNAORONITPV-UHFFFAOYSA-N |
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| SMILES | CCC(C)C1NC(=O)CNC(=O)C2Cc3c([nH]c4cc(O)ccc34)S(=O)CC(NC(=O)CNC1=O)C(=O)NC(CC(=O)O)C(=O)N1CC(O)CC1C(=O)NC(C(C)C(C)O)C(=O)N2 |
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Synonyms
