Introduction：Basic information about CAS 1989698-37-4|Lugdunin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Lugdunin |
|---|
| CAS Number | 1989698-37-4 | Molecular Weight | 783.03500 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C40H62N8O6S | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Lugdunin |
|---|
| Synonym | More Synonyms |
|---|
Lugdunin BiologicalActivity
| Description | Lugdunin is an antibiotic peptide. Lugdunin inhibits bacteria by dissipating their membrane potential. Lugdunin is active against Gram-positive bacteria, such as S. aureus, and reduces S. aureus skin and nasal colonization. Lugdunin induces LL-37 and CXCL8/MIP-2 in human keratinocytes and mouse skin[1]. |
|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
|---|
| References | [1]. Bitschar K, et al. Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors. Nat Commun. 2019 Jun 21;10(1):2730. |
|---|
Chemical & Physical Properties
| Molecular Formula | C40H62N8O6S |
|---|
| Molecular Weight | 783.03500 |
|---|
| Exact Mass | 782.45100 |
|---|
| PSA | 227.72000 |
|---|
| LogP | 4.63560 |
|---|
| InChIKey | QZNGYMKAHFFKCJ-ZBQZSICZSA-N |
|---|
| SMILES | CC(C)CC1NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(C(C)C)NC(=O)C2CSC(N2)C(C(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)C)NC1=O |
|---|
Synonyms
| (1R,4R,7S,10R,13S,16R,19S)-7-((1H-indol-3-yl)methyl)-10-isobutyl-4,13,16,19-tetraisopropyl-21-thia-3,6,9,12,15,18,23-heptaazabicyclo[18.2.1]tricosane-2,5,8,11,14,17-hexaone |
