Introduction：Basic information about CAS 99119-73-0|Kushenol C, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kushenol C |
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| CAS Number | 99119-73-0 | Molecular Weight | 438.47000 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C25H26O7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Kushenol C |
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| Synonym | More Synonyms |
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Kushenol C BiologicalActivity
| Description | Kushenol C, isolated from the roots of Sophora flavescens, shows anti-Inflammatory and anti-oxidative stress activities. Kushenol C inhibits BACE1 (β-site APP cleaving enzyme 1) with an IC50 of 5.45 µM[1][2]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Beta-secretaseResearch Areas >>Inflammation/Immunology |
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| In Vitro | Kushenol C dose-dependently suppresses the production of inflammatory mediators, including NO, PGE2, IL-6, IL1β, MCP-1, and IFN-β in LPS-stimulated RAW264.7 macrophages. Kushenol C (50-100 µM;) significantly decreases the phosphorylation of both STAT1 molecules and STAT6 in a dose-dependent manner in LPS-stimulated RAW264.7 cells[1]. Kushenol C upregulates the expression of HO-1 and its activities in the LPS-stimulated RAW264.7 macrophages. In HaCaT cells, Kushenol C prevents DNA damage and cell death by upregulating the endogenous antioxidant defense system involving glutathione, superoxide dismutase, and catalase, which prevents reactive oxygen species production from tert-butyl hydroperoxide (tBHP)-induced oxidative stress in HaCaT cells[1]. Kushenol C inhibits BChE and AChE with IC50s of 54.86 and 33.13 µM[2]. |
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| References | [1]. Cho BO, et al. In vitro Anti-Inflammatory and Anti-Oxidative Stress Activities of Kushenol C Isolated from the Roots of Sophoraflavescens. Molecules. 2020;25(8):1768. Published 2020 Apr 12. [2]. Jung HA, et al. Selective inhibition of prenylated flavonoids from Sophora flavescens against BACE1 and cholinesterases. Am J Chin Med. 2010;38(2):415-429. |
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Chemical & Physical Properties
| Molecular Formula | C25H26O7 |
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| Molecular Weight | 438.47000 |
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| Exact Mass | 438.16800 |
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| PSA | 131.36000 |
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| LogP | 5.07910 |
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| InChIKey | WAAPHYJTKSTXSX-CQSZACIVSA-N |
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| SMILES | C=C(C)C(CC=C(C)C)Cc1c(O)cc(O)c2c(=O)c(O)c(-c3ccc(O)cc3O)oc12 |
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Synonyms
| kushenol C |
| 2-(2,4-Dihydroxy-phenyl)-3,5,7-trihydroxy-8-(2-isopropenyl-5-methyl-hex-4-enyl)-chromen-4-one |
