CAS 216974-75-3|Bevacizumab

Introduction：Basic information about CAS 216974-75-3|Bevacizumab, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameBevacizumab
CAS Number216974-75-3Molecular Weight396.150
Density/Boiling Point/
Molecular FormulaC14H18ILiN2O3Melting Point/
MSDS/Flash Point/

Names

NameLithium 4-{[2-(diethylamino)ethyl]carbamoyl}-2-iodobenzoate
SynonymMore Synonyms

Bevacizumab BiologicalActivity

DescriptionBevacizumab, as a humanized vascular endothelial growth factor (VEGF) antibody, is a highly effective monoclonal antibody. Bevacizumab can be used for the research of cancer[1][2].
Related CatalogResearch Areas >>CancerSignaling Pathways >>Others >>Others
In VitroBevacizumab-loaded hydrogel results in significant tumor reduction. Bevacizumab is taken up by other organs, including the heart, lung, and spleen. Bevacizumab accumulates higher within tumors via Bevacizumab-loaded hydrogel administration from 14 days onward as compared to the solution formulation. Bevacizumab (I.v.) solution, a typical drug clearance profile is observed where the antibody is cleared from the circulatory system with a half-life of ~4~5 days. The Bevacizumab-loaded hydrogel and the weekly administration of Bevacizumab solution inhibits tumor growth/metastasis in the peritoneal cavity, while one-time i.v. injection of Bevacizumab solution does not provide any therapeutic effect, leading to extensive tumor metastasis[2].
References

[1]. Liu W, et al. Effect of Avastin on the migration and invasion of pterygium fibroblasts. Eye Sci. 2014;29(4):214-218.

[2]. Lee AL, et al. Injectable biodegradable hydrogels from vitamin D-functionalized polycarbonates for the delivery of avastin with enhanced therapeutic efficiency against metastatic colorectal cancer. Biomacromolecules. 2015;16(2):465-475.

Chemical & Physical Properties

Molecular FormulaC14H18ILiN2O3
Molecular Weight396.150
Exact Mass396.052216

Synonyms

Lithium 4-{[2-(diethylamino)ethyl]carbamoyl}-2-iodobenzoate
Benzoic acid, 4-[[[2-(diethylamino)ethyl]amino]carbonyl]-2-iodo-, lithium salt (1:1)
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