CAS 80449-31-6|Ulinastatin

Introduction：Basic information about CAS 80449-31-6|Ulinastatin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ulinastatin BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Ulinastatin
CAS Number	80449-31-6	Molecular Weight	220.264
Density	1.2±0.1 g/cm3	Boiling Point	331.5±42.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₆O₃	Melting Point	/
MSDS	/	Flash Point	171.0±16.8 °C

Names

Name	3-(2-Furyl)-2,4-dioxaspiro[5.5]undec-8-ene
Synonym	More Synonyms

Ulinastatin BiologicalActivity

Description	Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2].
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease
References	[1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726. [2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605.

Description

Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects[1][2].

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Ser/Thr ProteaseSignaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/ImmunologyResearch Areas >>Neurological Disease

References

[1]. Shangping Fang, et al. Research progress of ulinastatin in the treatment of liver diseases. Int J Clin Exp Pathol. 2020 Nov 1;13(11):2720-2726.

[2]. Cao C, et al. Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators. Shock. 2018 Nov;50(5):595-605.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	331.5±42.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₆O₃
Molecular Weight	220.264
Flash Point	171.0±16.8 °C
Exact Mass	220.109940
LogP	2.87
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.549
InChIKey	ODVKSTFPQDVPJZ-UHFFFAOYSA-N
SMILES	C1=CCC2(CC1)COC(c1ccco1)OC2
Storage condition	-20℃

Synonyms

3-(2-Furyl)-2,4-dioxaspiro[5.5]undec-8-ene

2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-

Ulinastatin

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