CAS 1469338-01-9|6H05

Introduction：Basic information about CAS 1469338-01-9|6H05, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 6H05 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	6H05
CAS Number	1469338-01-9	Molecular Weight	476.12
Density	1.4±0.1 g/cm3	Boiling Point	735.5±70.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₀ClN₃O₂S₃	Melting Point	/
MSDS	/	Flash Point	398.6±35.7 °C

Names

Name	(5Z)-5-(4-Ethylbenzylidene)-3-[4-oxo-4-(10H-phenothiazin-10-yl)butyl]-2-thioxo-1,3-thiazolidin-4-one
Synonym	More Synonyms

6H05 BiologicalActivity

Description	6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].
Related Catalog	Signaling Pathways >>GPCR/G Protein >>RasResearch Areas >>Cancer
References	[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.

Description

6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

Related Catalog

Signaling Pathways >>GPCR/G Protein >>RasResearch Areas >>Cancer

References

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51.

[2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Boiling Point	735.5±70.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₀ClN₃O₂S₃
Molecular Weight	476.12
Flash Point	398.6±35.7 °C
LogP	5.65
Vapour Pressure	0.0±2.4 mmHg at 25°C
Index of Refraction	1.752
InChIKey	WEEYMZOUPNIHLG-UHFFFAOYSA-N
SMILES	CN(C)CCSSCCNC(=O)C1CCN(C(=O)CSc2ccc(Cl)cc2)CC1
Storage condition	2~8°C

Safety Information

Hazard Codes	Xi

Synonyms

4-Thiazolidinone, 5-[(4-ethylphenyl)methylene]-3-[4-oxo-4-(10H-phenothiazin-10-yl)butyl]-2-thioxo-, (5Z)-

(5Z)-5-(4-Ethylbenzylidene)-3-[4-oxo-4-(10H-phenothiazin-10-yl)butyl]-2-thioxo-1,3-thiazolidin-4-one

6H05

Recommended......