CAS 11061-68-0|Insulin(human)
| Common Name | Insulin(human) | ||
|---|---|---|---|
| CAS Number | 11061-68-0 | Molecular Weight | 5807.58 |
| Density | / | Boiling Point | / |
| Molecular Formula | C257H383N65O77S6 | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | Insulin (human) |
|---|---|
| Synonym | More Synonyms |
Insulin(human) BiologicalActivity
| Description | Insulin(human) is a peptide hormone that regulates the level of sugar (glucose) in the blood and that is produced by the beta cells of the pancreatic islets. |
|---|---|
| Related Catalog | Signaling Pathways >>Protein Tyrosine Kinase/RTK >>Insulin ReceptorResearch Areas >>Metabolic DiseasePeptidesPeptides |
| In Vitro | The human insulin gene contains two intervening sequences, one is within the region transcribed into the 5'-untranslated segment of the mRNA and the other interrupts the C-peptide encoding region[1]. Human insulin is commonly used to treat type 2 diabetes[2]. |
| References | [1]. Bell GI, et al. Sequence of the human insulin gene. Nature. 1980 Mar 6;284(5751):26-32. [2]. Tseng CH, et al. Prolonged use of human insulin increases breast cancer risk in Taiwanese women with type 2 diabetes. BMC Cancer. 2015 Nov 4;15:846. |
Chemical & Physical Properties
| Molecular Formula | C257H383N65O77S6 |
|---|---|
| Molecular Weight | 5807.58 |
| Appearance of Characters | Solution |
| InChIKey | PBGKTOXHQIOBKM-FHFVDXKLSA-N |
| SMILES | CCC(C)C(NC(=O)CN)C(=O)NC(C(=O)NC(CCC(=O)O)C(=O)NC(CCC(N)=O)C(=O)NC1CSSCC2NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CSSCC(NC(=O)C(CC(C)C)NC(=O)C(Cc3c[nH]cn3)NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)Cc3ccccc3)C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(Cc3c[nH]cn3)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C)C(=O)NC(CC(C)C)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(Cc3ccccc3)C(=O)NC(Cc3ccc(O)cc3)C(=O)NC(C(=O)N3CCCC3C(=O)NC(CCCCN)C(=O)NC(C(=O)O)C(C)O)C(C)O)CSSCC(C(=O)NC(CC(N)=O)C(=O)O)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CC(N)=O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CCC(N)=O)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CC(C)C)NC(=O)C(CO)NC2=O)NC1=O)C(C)C |
| Storage condition | 2-8°C |
| Water Solubility | Soluble up to 10mg/ml in pH <3 or in the presence of surfactants. Adjusting pH with a volatile acid (such as formic acid) prior to dry down will allow the product to be re-dissolved in water. |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | NM8900250 |
Articles67
More Articles| Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes. Skelet. Muscle 5 , 26, (2015) In skeletal muscle, intracellular Ca(2+) is an important regulator of contraction as well as gene expression and metabolic processes. Because of the difficulties to obtain intact human muscle fibers, ... | |
| LipiD-QuanT: a novel method to quantify lipid accumulation in live cells. J. Lipid Res. 56 , 2206-16, (2015) Lipid droplets (LDs) are the main storage organelles for triglycerides. Elucidation of lipid accumulation mechanisms and metabolism are essential to understand obesity and associated diseases. Adipoge... | |
| Autophagosome-lysosome fusion is independent of V-ATPase-mediated acidification. Nat. Commun. 6 , 7007, (2015) The ATP-dependent proton pump V-ATPase ensures low intralysosomal pH, which is essential for lysosomal hydrolase activity. Based on studies with the V-ATPase inhibitor BafilomycinA1, lysosomal acidifi... |
Synonyms
| MFCD00131380 |
| Oral-lyn |
| Penfil R |
| Ultraphane |
| EINECS 234-279-7 |
| Umulin |
| Velosulin HM |
| ORMD 0801 |
| Insulin(human) |
