Introduction：Basic information about CAS 1198398-71-8|Coptisine sulfate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Coptisine sulfate |
|---|
| CAS Number | 1198398-71-8 | Molecular Weight | 417.389 |
|---|
| Density | / | Boiling Point | / |
|---|
| Molecular Formula | C19H15NO8S | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Coptisine sulfate |
|---|
| Synonym | More Synonyms |
|---|
Coptisine sulfate BiologicalActivity
| Description | Coptisine Sulfate is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM[1]. |
|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Metabolic Enzyme/Protease >>Indoleamine 2,3-Dioxygenase (IDO)Research Areas >>Metabolic Disease |
|---|
| Target | IC50: 6.3 μM (IDO)[1] Ki: 5.8 μM (IDO)[1] |
|---|
| References | [1]. Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302. |
|---|
Chemical & Physical Properties
| Molecular Formula | C19H15NO8S |
|---|
| Molecular Weight | 417.389 |
|---|
| Exact Mass | 417.051849 |
|---|
| InChIKey | MHVVFMWLVSKBQZ-UHFFFAOYSA-L |
|---|
| SMILES | O=S(=O)([O-])[O-].c1c2c(cc3c1OCO3)-c1cc3ccc4c(c3c[n+]1CC2)OCO4.c1c2c(cc3c1OCO3)-c1cc3ccc4c(c3c[n+]1CC2)OCO4 |
|---|
Synonyms
| 6,7-Dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquinolino[3,2-a]isoquinolin-5-ium hydrogen sulfate |
| Coptisine sulfate |
