Introduction：Basic information about CAS 1515856-92-4|XEN445, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | XEN445 |
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| CAS Number | 1515856-92-4 | Molecular Weight | 366.334 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 490.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H17F3N2O3 | Melting Point | / |
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| MSDS | / | Flash Point | 250.7±28.7 °C |
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Names
| Name | 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid |
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| Synonym | More Synonyms |
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XEN445 BiologicalActivity
| Description | XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.IC50 value: 0.237 uM [1]Target: Endothelial lipase inhibitorXEN445 can be readily prepared in good yield from commercial available chemicals, which was selected for further evaluation of this series of EL inhibitors. After a 30 min preincubation of EL-expressing HEK cells with XEN445, the IC50 value for XEN445 of 0.25 lM was obtained. This value was very similar to that determined in the cell-free assay. Wild-type mice were orally dosed with XEN445 at 30 mg/kg b.i.d. for 3 days and blood was taken on the morning of day 4, 16 h post final dose. At termination, the average plasma levels of XEN445 was 9.9 lM and the drug caused an 18% and 16% increase in total plasma cholesterol and HDLc, respectively. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Cardiovascular Disease |
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| References | [1]. Sun S, et al. Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice. Bioorg Med Chem. 2013 Dec 15;21(24):7724-34. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 490.9±45.0 °C at 760 mmHg |
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| Molecular Formula | C18H17F3N2O3 |
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| Molecular Weight | 366.334 |
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| Flash Point | 250.7±28.7 °C |
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| Exact Mass | 366.119141 |
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| LogP | 3.30 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.583 |
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| InChIKey | NBGRERFNOKZQLO-AWEZNQCLSA-N |
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| SMILES | O=C(O)c1cc(C(F)(F)F)ccc1N1CCC(OCc2ccccn2)C1 |
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| Storage condition | -20℃ |
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Safety Information
| RIDADR | NONH for all modes of transport |
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Synonyms
| Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)- |
| 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid |
| (S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL |
| XEN-445 |
| XEN445 |
