CAS 90954-53-3|α-CGRP (human) trifluoroacetate salt

Introduction：Basic information about CAS 90954-53-3|α-CGRP (human) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. α-CGRP (human) trifluoroacetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles4
6. Synonyms

Common Name	α-CGRP (human) trifluoroacetate salt
CAS Number	90954-53-3	Molecular Weight	3789.31
Density	/	Boiling Point	/
Molecular Formula	C₁₆₃H₂₆₇N₅₁O₄₉S₂	Melting Point	/
MSDS	USA	Flash Point	/

Names

Name	2-[(4R,7S,10S,13S,16S,19R)-4-[[(1S)-1-[[(1S,2R)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[2-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-3-amino-1-[[(1S)-3-amino-1-[[(1S)-2-[[(1S)-1-[(2S)-2-[[(1S,2R)-1-[[(1S)-3-amino-1-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-2-[[(1S)-2-amino-1-benzyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-propyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-4-guanidino-butyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]-19-[[(2S)-2-aminopropanoyl]amino]-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]acetic acid
Synonym	More Synonyms

Name

2-[(4R,7S,10S,13S,16S,19R)-4-[[(1S)-1-[[(1S,2R)-1-[[(1S)-2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-2-[[(1S)-1-[[(1S)-2-[[2-[[2-[[(1S)-1-[[(1S)-1-[[(1S)-5-amino-1-[[(1S)-3-amino-1-[[(1S)-3-amino-1-[[(1S)-2-[[(1S)-1-[(2S)-2-[[(1S,2R)-1-[[(1S)-3-amino-1-[[(1S)-1-[[2-[[(1S)-2-[[(1S)-5-amino-1-[[(1S)-2-[[(1S)-2-amino-1-benzyl-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]pentyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]amino]-2-oxo-ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-propyl]amino]-1-benzyl-2-oxo-ethyl]carbamoyl]-3-oxo-propyl]carbamoyl]-3-oxo-propyl]carbamoyl]pentyl]carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]amino]-2-oxo-ethyl]amino]-2-oxo-ethyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-4-guanidino-butyl]amino]-1-(hydroxymethyl)-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-2-oxo-ethyl]amino]-1-methyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-4-guanidino-butyl]amino]-1-(1H-imidazol-4-ylmethyl)-2-oxo-ethyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]-2-methyl-propyl]carbamoyl]-19-[[(2S)-2-aminopropanoyl]amino]-7,13-bis[(1R)-1-hydroxyethyl]-10-methyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicos-16-yl]acetic acid

Synonym

More Synonyms

α-CGRP (human) trifluoroacetate salt BiologicalActivity

Description	α-CGRP(human) is a regulatory neuropeptide of 37 amino acids. α-CGRP(human) is widely distributed in the central and peripheral nervous system. α-CGRP(human) is a potent vasodilator[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others
References	[1]. Ambrish Kumar, et al. Protective Role of α-Calcitonin Gene-Related Peptide in Cardiovascular Diseases. Front Physiol. 2019 Jul 2;10:821.

Chemical & Physical Properties

Molecular Formula	C₁₆₃H₂₆₇N₅₁O₄₉S₂
Molecular Weight	3789.31
InChIKey	DNKYDHSONDSTNJ-XJVRLEFXSA-N
SMILES	CC(C)CC(NC(=O)CNC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(Cc1cnc[nH]1)NC(=O)C(NC(=O)C(NC(=O)C(CS)NC(=O)C(NC(=O)C(C)NC(=O)C(NC(=O)C(CC(=O)O)NC(=O)C(CS)NC(=O)C(C)N)C(C)O)C(C)O)C(C)C)C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(CC(N)=O)C(=O)NC(CC(N)=O)C(=O)NC(Cc1ccccc1)C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NCC(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C)C(=O)NC(Cc1ccccc1)C(N)=O)C(C)C)C(C)O)C(C)C)C(C)C)C(C)C
Storage condition	-20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3.0

Articles4

STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition.

Mol. Cell. Endocrinol. 403 , 78-87, (2015)

Stanniocalcin 1 (STC1) and calcitonin gene-related peptide (CGRP) are involved in bone formation/remodeling. Here we investigate the effects of STC1 on functional heterodimer complex CALCRL/RAMP1, exp...

Increasing expression of substance P and calcitonin gene-related peptide in synovial tissue and fluid contribute to the progress of arthritis in developmental dysplasia of the hip.

Arthritis. Res. Ther. 17(1) , 4, (2015)

Developmental dysplasia of the hip (DDH) is a common musculoskeletal disorder that has pain and loss of joint function as major pathological features. In the present study, we explored the mechanisms ...

The role of TRPV1 in different subtypes of dorsal root ganglion neurons in rat chronic inflammatory nociception induced by complete Freund's adjuvant.

Mol. Pain 4 , 61, (2008)

The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons in chronic pain including thermal hyperalgesia and mechanical a...

Synonyms

Human calcitonin gene-related peptide 1

alpha-Calcitonin gene-related peptide (human)

β-CGRP (human)

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