Introduction：Basic information about CAS 1193447-34-5|CRANAD-2, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | CRANAD-2 |
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| CAS Number | 1193447-34-5 | Molecular Weight | 410.26500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C23H25BF2N2O2 | Melting Point | / |
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| MSDS | ChineseUSA | Flash Point | / |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | CRANAD-2 |
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| Synonym | More Synonyms |
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CRANAD-2 BiologicalActivity
| Description | CRANAD-2 is a near-infrared (NIR) Aβ plaque-specific fluorescent probe. CRANAD 2 penetrates the blood brain barrier and has a high affinity for Aβ aggregates with a Kd of 38 nM[1][2]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| References | [1]. Ran C, et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc. 2009 Oct 28;131(42):15257-61. [2]. Ran C, et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One. 2011 Apr 29;6(4):e19362. |
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Chemical & Physical Properties
| Molecular Formula | C23H25BF2N2O2 |
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| Molecular Weight | 410.26500 |
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| Exact Mass | 410.19800 |
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| PSA | 32.78000 |
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| LogP | 4.93870 |
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| InChIKey | PVXQJYXODFZTBR-UHFFFAOYSA-N |
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| SMILES | CN(C)c1ccc(C=CC2=CC(=CC=C3C=CC(=[N+](C)C)C=C3)O[B-](F)(F)O2)cc1 |
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| Storage condition | 2-8°C |
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| Water Solubility | DMSO: soluble 0.2 mg/mL, clear (warmed) |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H315-H319 |
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| Precautionary Statements | P305 + P351 + P338 |
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| Hazard Codes | Xi |
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| RIDADR | NONH for all modes of transport |
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Synonyms
| (T-4)-[(1E,6E)-1,7-bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-dionato-kO3,kO5]difluoro-boron |
