Introduction：Basic information about CAS 202801-92-1|Orexin B (mouse, rat), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Orexin B (mouse, rat) |
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| CAS Number | 202801-92-1 | Molecular Weight | 2936.401 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C126H215N45O34S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Orexin B |
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| Synonym | More Synonyms |
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Orexin B (mouse, rat) BiologicalActivity
| Description | Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Orexin Receptor (OX Receptor)Research Areas >>Neurological DiseasePeptides |
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| Target | Ki: 420 nM (OX1), 36 nM (OX2)[1] |
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| In Vitro | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. |
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| In Vivo | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2]. |
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| Animal Admin | Rats[2] 3 nM and 30 nM of synthetic human Orexin B is administered in a 5 mL bolus through a catheter placed in the left lateral ventricle of Male Wistar rats (180–200 g) in early light phase. Cumulative food consumption is observed and plotted over the period of 4 hr after injection[2]. |
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| References | [1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Molecular Formula | C126H215N45O34S |
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| Molecular Weight | 2936.401 |
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| Exact Mass | 2934.619873 |
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| LogP | -9.21 |
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| Index of Refraction | 1.670 |
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| InChIKey | RLVZFBVFVIDDPQ-GWQFQBPDSA-N |
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| SMILES | CCC(C)C(NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)CNC(=O)C1CCCN1C(=O)C(N)CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCSC)C(N)=O)C(C)O |
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| Storage condition | −20°C |
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| Water Solubility | Soluble in 1% acetic acid at 1mg/ml |
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Safety Information
Synonyms
| L-Arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparaginylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide |
| L-Methioninamide, L-arginyl-L-prolylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-asparaginylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl- |
| Orexin B, rat, mouse |
