Introduction：Basic information about CAS 9009-65-8|Protamine sulfates, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Protamine sulfates |
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| CAS Number | 9009-65-8 | Molecular Weight | 6691.85629 |
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| Density | 2.2±0.1 g/cm3 | Boiling Point | 330.0±11.0 °C at 760 mmHg |
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| Molecular Formula | C264H460N128O65S7 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Protamine sulfates |
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| Synonym | More Synonyms |
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Protamine sulfates BiologicalActivity
| Description | Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer[1][2][3]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>ThrombinResearch Areas >>Metabolic Disease |
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| In Vitro | Protamine sulfate has an inhibitory effect on thrombin in the conversion of fibrinogen to fibrin, and that this inhibition is concentration dependent, partial, and reversible[3]. Protamine sulfate is a 5-kDa cationic polypeptide derived from salmon sperm that can bind negatively charged unfractionated heparin (UFH). Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation[4]. |
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| References | [1]. Ahmed Kouta, et al. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544. [2]. F L Sorgi, et al. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8. [3]. R J Cobel-Geard, et al. Interaction of protamine sulfate with thrombin. Am J Hematol. 1983 May;14(3):227-33. [4]. Fionnuala Ni Ainle, et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood. 2009 Aug 20;114(8):1658-65. |
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Chemical & Physical Properties
| Density | 2.2±0.1 g/cm3 |
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| Boiling Point | 330.0±11.0 °C at 760 mmHg |
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| Molecular Formula | C264H460N128O65S7 |
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| Molecular Weight | 6691.85629 |
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| Exact Mass | 6687.46695 |
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| LogP | -1.03 |
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| Appearance of Characters | amorphous powder | white |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.537 |
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| Storage condition | +2C to +8C |
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| Water Solubility | H2O: 10 mg/mL | It is sparingly soluble in water. |
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Safety Information
| Safety Phrases | 22-24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | VO9470000 |
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Synonyms
| H2SO4 |
| EINECS 236-903-3 |
| Oil of vitriol |
| MFCD00064589 |
| UNII:0DE9724IHC |
| Sulfate, hydrogen |
| Sulfuric(VI) acid |
| Sulfuric acid |
| Sulphuric acid |
