Introduction：Basic information about CAS 113-69-9|Benzquinamide hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Benzquinamide hydrochloride |
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| CAS Number | 113-69-9 | Molecular Weight | 440.96 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C22H33ClN2O5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 3-carbamoyl-N,N-diethyl-1,3,4,6,7,11b-hexahydro-9,11-dimethoxy-2H-benzo[a]quinolizin-2-yl acetate hydrochloride |
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| Synonym | More Synonyms |
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Benzquinamide hydrochloride BiologicalActivity
| Description | Benzquinamide (P2647) is an antiemetic which can bind to the α2A, α2B, and α2C adrenergic receptors (α2-AR) with Ki values of 1,365, 691, and 545 nM, respectively. Benzquinamide also inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells[1][2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
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| Target | Ki: 1,365, 691, and 545 nM (α2A, α2B,α2C receptor)[1] |
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| References | [1]. Elisabet Gregori-Puigjané, et al. Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28): 11178-11183. [2]. Mazzanti R, et al. Benzquinamide inhibits P-glycoprotein mediated drug efflux and potentiates anticancer agent cytotoxicity in multidrug resistant cells. Oncol Res. 1992;4(8-9):359-65. |
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Chemical & Physical Properties
| Molecular Formula | C22H33ClN2O5 |
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| Molecular Weight | 440.96 |
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| InChIKey | KZLNXGBVFTWMPS-UHFFFAOYSA-N |
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| SMILES | CCN(CC)C(=O)C1CN2CCc3cc(OC)c(OC)cc3C2CC1OC(C)=O.Cl |
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Synonyms
