Introduction：Basic information about CAS 205640-91-1|Orexin B (human) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Orexin B (human) trifluoroacetate salt |
|---|
| CAS Number | 205640-91-1 | Molecular Weight | 2899.338 |
|---|
| Density | 1.5±0.1 g/cm3 | Boiling Point | / |
|---|
| Molecular Formula | C123H212N44O35S | Melting Point | / |
|---|
| MSDS | / | Flash Point | / |
|---|
Names
| Name | Orexin B(human) |
|---|
| Synonym | More Synonyms |
|---|
Orexin B (human) trifluoroacetate salt BiologicalActivity
| Description | Orexin B, human is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively. |
|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Orexin Receptor (OX Receptor)PeptidesResearch Areas >>Neurological Disease |
|---|
| Target | Ki: 420 nM (OX1), 36 nM (OX2)[1] |
|---|
| In Vitro | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor[1]. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC50 of 36 nM in the binding assay and an EC50 of 60 nM in the [Ca2+]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC50 in the competitive binding assay and the EC50 in the [Ca2+]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively[2]. |
|---|
| In Vivo | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively[2]. |
|---|
| Animal Admin | Rats[2] 3 nM and 30 nM of synthetic human Orexin B is administered in a 5 mL bolus through a catheter placed in the left lateral ventricle of Male Wistar rats (180–200 g) in early light phase. Cumulative food consumption is observed and plotted over the period of 4 hr after injection[2]. |
|---|
| References | [1]. Smart D, et al. Orexins: a new family of neuropeptides. Br J Anaesth. 1999 Nov;83(5):695-7. [2]. Sakurai T, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20;92(4):573-85. |
|---|
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|
| Molecular Formula | C123H212N44O35S |
|---|
| Molecular Weight | 2899.338 |
|---|
| Exact Mass | 2897.588135 |
|---|
| LogP | -9.29 |
|---|
| Index of Refraction | 1.665 |
|---|
| InChIKey | DHBREICAXZPFDD-WMQZXSDYSA-N |
|---|
| SMILES | CCC(C)C(NC(=O)CNC(=O)C(C)NC(=O)C(C)NC(=O)C(Cc1c[nH]cn1)NC(=O)C(CC(N)=O)NC(=O)CNC(=O)C(CO)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C1CCCN1C(=O)C1CCCN1C(=O)CNC(=O)C(CO)NC(=O)C(N)CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCSC)C(N)=O)C(C)O |
|---|
| Storage condition | −20°C |
|---|
Safety Information
Synonyms
| L-Methioninamide, L-arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl- |
| L-Arginyl-L-serylglycyl-L-prolyl-L-prolylglycyl-L-leucyl-L-glutaminylglycyl-L-arginyl-L-leucyl-L-glutaminyl-L-arginyl-L-leucyl-L-leucyl-L-glutaminyl-L-alanyl-L-serylglycyl-L-asparaginyl-L-histidyl-L-alanyl-L-alanylglycyl-L-isoleucyl-L-leucyl-L-threonyl-L-methioninamide |
| RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2 |
