CAS 9073-60-3|β-LactaMase
| Common Name | β-LactaMase | ||
|---|---|---|---|
| CAS Number | 9073-60-3 | Molecular Weight | / |
| Density | / | Boiling Point | / |
| Molecular Formula | / | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Danger |
Names
| Name | β-Lactamase |
|---|---|
| Synonym | More Synonyms |
β-LactaMase BiologicalActivity
| Description | β-Lactamase is the enzyme produced by bacteria. β-Lactamase mediates β-lactam resistance[1]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| In Vitro | 在革兰氏阴性菌中，水解四元 β-内酰胺环的酰胺键是 β-Lactamase 主要的耐药机制，多种酶散布在机会致病菌：肠杆菌科 (如大肠杆菌) 和非发酵生物 (如铜绿假单胞菌) 的移动遗传元件上。β-Lactamase 分为四类：活性位点丝氨酸 β-Lactamase (A、C 和 D 类) 和锌依赖性或金属 β-Lactamase (MBLs; B 类)[1]。 |
| References | [1]. Tooke CL, et al. β-Lactamases and β-Lactamase Inhibitors in the 21st Century. J Mol Biol. 2019 Aug 23;431(18):3472-3500. |
Chemical & Physical Properties
| InChIKey | PFVWVVUSAORMBB-VQIMIIECSA-N |
|---|---|
| SMILES | O=C(Cc1cccs1)NC1C(=O)N2C(C(=O)O)=C(CSc3ccc([N+](=O)[O-])c(C(=O)O)c3)CSC12 |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H317-H334 |
| Precautionary Statements | P261-P280-P342 + P311 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3.0 |
| RTECS | OD2265000 |
Preparation
Articles69
More Articles| A Novel Microbisporicin Producer Identified by Early Dereplication during Lantibiotic Screening. Biomed Res. Int. 2015 , 419383, (2015) With the increasing need of effective antibiotics against multi-drug resistant pathogens, lantibiotics are an attractive option of a new class of molecules. They are ribosomally synthetized and posttr... | |
| Identification of peptide inhibitors of penicillinase using a phage display library. Anal. Biochem. 494 , 4-9, (2015) There is a constant need to identify novel inhibitors to combat β-lactamase-mediated antibiotic resistance. In this study, we identify three penicillinase-binding peptides, P1 (DHIHRSYRGEFD), P2 (NIYT... | |
| Outbreak of PER-1 and diversity of β-lactamases among ceftazidime-resistant Pseudomonas aeruginosa clinical isolates. J. Med. Microbiol. 63(Pt 3) , 386-92, (2014) A growing number of β-lactamases have been reported in Pseudomonas aeruginosa clinical isolates. The aim of this study was to investigate the diversity of β-lactamases in the collection of 51 ceftazid... |
Synonyms
| MFCD00131819 |
