Introduction：Basic information about CAS 99658-03-4|α-Helical CRF (9-41) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | α-Helical CRF (9-41) trifluoroacetate salt |
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| CAS Number | 99658-03-4 | Molecular Weight | 3826.36 |
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| Density | 1.5±0.1 g/cm3 | Boiling Point | 717.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C166H274N46O53S2 | Melting Point | / |
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| MSDS | USA | Flash Point | 387.5±32.9 °C |
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Names
| Name | Corticotropin Releasing Factor Antagonist |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | α-Helical Corticotropin Releasing Factor (9-41) is a corticotropin releasing factor (CRF) antagonist. α-Helical Corticotropin Releasing Factor (9-41) decreases plasma growth hormone (GH) values in vivo[1][2]. |
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| Related Catalog | Signaling Pathways >>GPCR/G Protein >>CRFRResearch Areas >>Inflammation/Immunology |
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| In Vivo | α-Helical Corticotropin Releasing Factor (9-41) (10 μg; the third or lateral ventricle of the brain injection; once) significantly decreases plasma GH values[1]. α-Helical Corticotropin Releasing Factor (9-41) (100 ng/kg; i.c.v. once) affects rhlL-1/β-induced enhancement of the splenic sympathetic activity[2]. Animal Model: Adult Sprague-Dawley rats[1] Dosage: 10 μg Administration: The third or lateral ventricle of the brain injection; 10 μg once Result: Abolished the 10 min electroshocks-produced the decreasing of plasma GH levels by injected into the third or lateral ventricle of the brain 45 min before exposure to stress. Animal Model: Adult Sprague-Dawley rats with immunity of endogenous somatostatin (SS)[1] Dosage: 10 μg Administration: Lateral ventricle brain injection; 10 μg once Result: Showed no effect on plasma GH values in rats whose endogenous SS had been immunoneutralized, but did interfere with the stimulatory effect of GH-releasing factor (GRF). Animal Model: Male Wistar rats with rhlL-1/β injection[2] Dosage: 100 ng/kg Administration: Intracerebroventricularly injection; 100 ng/kg once Result: Completely blocked the rhlL-1/β-induced enhancement of the splenic sympathetic activity, but failed to alter the enhancement of nociceptive behaviors caused by rhlL-1/β. |
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| References | [1]. Rivier C, Vale W. Involvement of corticotropin-releasing factor and somatostatin in stress-induced inhibition of growth hormone secretion in the rat. Endocrinology. 1985 Dec;117(6):2478-82. [2]. Takakazu Oka, et al. Intracerebroventricular injection of interleukin-1/β induces hyperalgesia in rats. Brain Research, 624 (1993) 61-68. |
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Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
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| Boiling Point | 717.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C166H274N46O53S2 |
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| Molecular Weight | 3826.36 |
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| Flash Point | 387.5±32.9 °C |
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| Exact Mass | 540.075745 |
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| LogP | 3.33 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.602 |
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| InChIKey | QDUCLNZKQMUVKX-MJGOQNOKSA-N |
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| SMILES | COC(=O)C(Cc1ccccc1I)NC(=O)CC(O)CNC(=O)OCc1ccccc1 |
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Articles2
More Articles
| Modulation of Sleep Homeostasis by Corticotropin Releasing Hormone in REM Sleep-Deprived Rats. Int. J. Endocrinol. 2010 , 326151, (2010) Studies have shown that sleep recovery following different protocols of forced waking varies according to the level of stress inherent to each method. Sleep deprivation activates the hypothalamic-pitu... | |
| Play fighting and corticotropin-releasing hormone in the lateral septum of golden hamsters. Neuroscience 169 , 236-45, (2010) This study was focused on determining the possible role of corticotropin-releasing hormone (CRH) on play fighting in juvenile golden hamsters. As no specific neural sites have been proposed, we looked... | |
Synonyms
