Introduction：Basic information about CAS 1573029-17-0|4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline |
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| CAS Number | 1573029-17-0 | Molecular Weight | 282.312 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 470.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C17H15FN2O | Melting Point | / |
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| MSDS | / | Flash Point | 238.2±28.7 °C |
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Names
| Name | 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1]. |
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| Related Catalog | Research Areas >>Neurological Disease |
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| In Vivo | THK-523 crosses the blood–brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. Animal Model: Brain of tau transgenic mice[1] Dosage: 0.35 μg/kg Administration: Intravenous injection;25-30 mins Result: Overexpressed Tau in brain. |
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| References | [1]. Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):125-32. [2]. Michelle T Fodero-Tavoletti, 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain. 2011 Apr;134(Pt 4):1089-100. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 470.3±45.0 °C at 760 mmHg |
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| Molecular Formula | C17H15FN2O |
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| Molecular Weight | 282.312 |
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| Flash Point | 238.2±28.7 °C |
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| Exact Mass | 282.116852 |
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| LogP | 3.01 |
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| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
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| Index of Refraction | 1.635 |
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| InChIKey | ZGJOXECWZKCGBV-UHFFFAOYSA-N |
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| SMILES | Nc1ccc(-c2ccc3cc(OCCF)ccc3n2)cc1 |
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Synonyms
| 4-[6-(2-Fluoroethoxy)-2-quinolinyl]aniline |
| Benzenamine, 4-[6-(2-fluoroethoxy)-2-quinolinyl]- |
| THK-523 |
