CAS 1557267-42-1|Avitinib

Introduction：Basic information about CAS 1557267-42-1|Avitinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Avitinib BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Avitinib
CAS Number	1557267-42-1	Molecular Weight	487.529
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₂₆H₂₆FN₇O₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	N-{3-[(2-{[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}acrylamide
Synonym	More Synonyms

Avitinib BiologicalActivity

Description	Avitinib (AC0010) is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR T790M resistance mutations in non-small cell lung cancer (NSCLC). Abivertinib is also a novel BTK inhibitor.
Related Catalog	Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Btk
References	[1]. Xu X, Mao L, Xu W, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016;15(11):2586-2597. [2]. Yan X, Zhou Y, Huang S, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706.

Description

Avitinib (AC0010) is an irreversible, mutant-selective EGFR inhibitor that effectively inhibits EGFR T790M resistance mutations in non-small cell lung cancer (NSCLC). Abivertinib is also a novel BTK inhibitor.

Related Catalog

Research Areas >>CancerSignaling Pathways >>JAK/STAT Signaling >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>EGFRSignaling Pathways >>Protein Tyrosine Kinase/RTK >>Btk

References

[1]. Xu X, Mao L, Xu W, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016;15(11):2586-2597.

[2]. Yan X, Zhou Y, Huang S, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Molecular Formula	C₂₆H₂₆FN₇O₂
Molecular Weight	487.529
Exact Mass	487.213196
LogP	3.50
Index of Refraction	1.697
InChIKey	UOFYSRZSLXWIQB-UHFFFAOYSA-N
SMILES	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)c(F)c3)nc3[nH]ccc23)c1
Storage condition	-20℃

Synonyms

N-{3-[(2-{[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl}acrylamide

2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-

Avitinib

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