CAS 1234563-16-6|Epetraborole hydrochloride

Introduction：Basic information about CAS 1234563-16-6|Epetraborole hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Epetraborole hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Epetraborole hydrochloride
CAS Number	1234563-16-6	Molecular Weight	273.521
Density	/	Boiling Point	/
Molecular Formula	C₁₁H₁₇BClNO₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	(3S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)-2,1-benzoxaborol-1(3H)-ol hydrochloride (1:1)
Synonym	More Synonyms

Epetraborole hydrochloride BiologicalActivity

Description	Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase". It is intended for the treatment of infections caused by Gram-negative bacteria. Epetraborole hydrochloride is a bacteriostatic compound that can against a wide range of anaerobic and Gram-negative bacteria, including multidrug-resistant pathogens, such as extended-spectrum-β-lactamase-, metallo-β-lactamase-, and carbapenemase-producing organism.
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Infection
References	[1]. Goldstein EJ et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms.Antimicrob Agents Chemother. 2013 May;57(5):2401-4. [2]. O'Dwyer K et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment ofcomplicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.

Description

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase". It is intended for the treatment of infections caused by Gram-negative bacteria. Epetraborole hydrochloride is a bacteriostatic compound that can against a wide range of anaerobic and Gram-negative bacteria, including multidrug-resistant pathogens, such as extended-spectrum-β-lactamase-, metallo-β-lactamase-, and carbapenemase-producing organism.

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Infection

References

[1]. Goldstein EJ et al. Comparative in vitro activities of GSK2251052, a novel boron-containing leucyl-tRNA synthetase inhibitor, against 916 anaerobic organisms.Antimicrob Agents Chemother. 2013 May;57(5):2401-4.

[2]. O'Dwyer K et al. Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment ofcomplicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.

Chemical & Physical Properties

Molecular Formula	C₁₁H₁₇BClNO₄
Molecular Weight	273.521
Exact Mass	273.093903
InChIKey	DADYQGIQOBJGIW-HNCPQSOCSA-N
SMILES	Cl.NCC1OB(O)c2c(OCCCO)cccc21
Storage condition	2-8℃

Synonyms

(3S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)-2,1-benzoxaborol-1(3H)-ol hydrochloride (1:1)

1-Propanol, 3-[[(3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl]oxy]-, hydrochloride (1:1)

Epetraborole HCl

Epetraborole hydrochloride

AN3365

Epetraborole (hydrochloride)

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