CAS 591778-70-0|CP-640186 hydrochloride

Introduction：Basic information about CAS 591778-70-0|CP-640186 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. CP-640186 hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	CP-640186 hydrochloride
CAS Number	591778-70-0	Molecular Weight	522.078
Density	/	Boiling Point	/
Molecular Formula	C₃₀H₃₆ClN₃O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)
Synonym	More Synonyms

CP-640186 hydrochloride BiologicalActivity

Description	CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.
Related Catalog	Signaling Pathways >>Metabolic Enzyme/Protease >>Acetyl-CoA CarboxylaseResearch Areas >>Metabolic Disease
References	[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111. [2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.

Description

CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.

Related Catalog

Signaling Pathways >>Metabolic Enzyme/Protease >>Acetyl-CoA CarboxylaseResearch Areas >>Metabolic Disease

References

[1]. Harwood HJ Jr, et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem. 2003 Sep 26;278(39):37099-111.

[2]. Yamashita T, et al. Design, synthesis, and structure-activity relationships of spirolactones bearing 2-ureidobenzothiophene as acetyl-CoA carboxylases inhibitors. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.

Chemical & Physical Properties

Molecular Formula	C₃₀H₃₆ClN₃O₃
Molecular Weight	522.078
Exact Mass	521.244507
InChIKey	DUBNXJIOBFRASV-GJFSDDNBSA-N
SMILES	Cl.O=C(c1c2ccccc2cc2ccccc12)N1CCC(N2CCCC(C(=O)N3CCOCC3)C2)CC1
Storage condition	2-8℃

Synonyms

9-Anthryl[(3R)-3-(4-morpholinylcarbonyl)-1,4'-bipiperidin-1'-yl]methanone hydrochloride (1:1)

Methanone, 9-anthracenyl[(3R)-3-(4-morpholinylcarbonyl)[1,4'-bipiperidin]-1'-yl]-, hydrochloride (1:1)

CP-640186 hydrochloride

CP-640186 (hydrochloride)

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