Introduction：Basic information about CAS 1459687-89-8|GJ103, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GJ103 |
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| CAS Number | 1459687-89-8 | Molecular Weight | 342.378 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C16H14N4O3S | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | GJ103 |
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| Synonym | More Synonyms |
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GJ103 BiologicalActivity
| Description | GJ103 is a read-through compound that can induce read through of premature stop codons. GJ103 has potential for the research of genetic disorders caused by nonsense mutations[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vivo | GJ103 (10-30 μM; 4 days) 在具有纯合 TGA 突变和纯合 TAA 突变的 AT153LA 细胞中诱导 ATM 激酶活性[1]。 GJ103 在浓度高达 300 µM 时对 A-T 细胞没有表现出明显的细胞毒性[1]。 |
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| References | [1]. Du L, et, al. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. |
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Chemical & Physical Properties
| Molecular Formula | C16H14N4O3S |
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| Molecular Weight | 342.378 |
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| Appearance of Characters | yellow |
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| InChIKey | GBVQSAZHPCDBDY-UHFFFAOYSA-N |
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| SMILES | COc1cccc(-n2c(SCC(=O)O)nnc2-c2ccccn2)c1 |
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Synonyms
| 2-(4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid |
