Introduction：Basic information about CAS 118812-69-4|ularitide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ularitide |
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| CAS Number | 118812-69-4 | Molecular Weight | 3505.927 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C145H234N52O44S3 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | ularitide |
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| Synonym | More Synonyms |
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ularitide BiologicalActivity
| Description | Ularitide (Urodilatin), natriuretic peptide, is a vasodilator. Ularitide binds to and activates renal receptors. Ularitide also regulates renal dopamine metabolism Ularitide can be used in the research of heart failure[1][2][4][5]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
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| In Vitro | Ularitide increases the amount of cyclic nucleotides and decreases the raise in permeability in HUVEC cells[2]. Ularitide (1 nM-1 μM, 15 min) reverses methacholine-evoked contraction in bovine bronchi[3]. Ularitide (1 μM, 0-300 s) increases cyclic GMP levels in the presence of phosphoramidon in bovine bronchi[3]. |
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| In Vivo | Ularitide (10 nmol/kg, s.c., once) increases in urine volume and sodium excretion in arteriovenous (AV) fistula dogs[1]. Animal Model: Female dogs with or without surgically induced chronic aortocaval fistula[1] Dosage: 5 and 10 pmol/kg/min Administration: i.v. infusions for for 75 min, and thereafter at 10 pmol/kg/min for another 75 min. Result: Increased in urine volume and sodium excretion with high-output CHF. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C145H234N52O44S3 |
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| Molecular Weight | 3505.927 |
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| Exact Mass | 3503.683350 |
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| LogP | -16.35 |
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| Index of Refraction | 1.692 |
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Synonyms
| ularitide |
| Urodilatin (human) |
